Gem-associated protein 7

Last updated
GEMIN7
Protein GEMIN7 PDB 1y96.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GEMIN7 , SIP3, gem nuclear organelle associated protein 7
External IDs OMIM: 607419 MGI: 1916981 HomoloGene: 11668 GeneCards: GEMIN7
Orthologs
SpeciesHumanMouse
Entrez

79760

69731

Ensembl

ENSG00000142252

ENSMUSG00000044709

UniProt

Q9H840

Q9CWY4

RefSeq (mRNA)

NM_001007269
NM_001007270
NM_024707
NM_001319054
NM_001319055

Contents

NM_027189

RefSeq (protein)

NP_001007270
NP_001007271
NP_001305983
NP_001305984
NP_078983

NP_081465

Location (UCSC) Chr 19: 45.08 – 45.09 Mb Chr 7: 19.3 – 19.31 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. [5] [6] The gem-associated proteins are those found in the gems of Cajal bodies.

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [6]

Interactions

Gem-associated protein 7 has been shown to interact with SMN1 [5] [7] and Gem-associated protein 6. [5] [8]

Related Research Articles

Gideon Dreyfuss is an American biochemist, the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine, and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

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<span class="mw-page-title-main">Gem-associated protein 2</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.

<span class="mw-page-title-main">DDX20</span> Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein polypeptide F</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Nucleolar protein, member A1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Gem-associated protein 6</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

<span class="mw-page-title-main">Gem-associated protein 4</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

<span class="mw-page-title-main">Gem-associated protein 5</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

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<span class="mw-page-title-main">GEMIN8</span> Protein-coding gene in humans

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142252 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044709 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–31962. doi: 10.1074/jbc.M203478200 . PMID   12065586.
  6. 1 2 "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
  7. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–7545. doi: 10.1074/jbc.M110141200 . PMID   11748230.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading


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