NCAPH2

NCAPH2
Identifiers
Aliases	NCAPH2 , CAPH2, non-SMC condensin II complex subunit H2
External IDs	OMIM: 611230 MGI: 1289164 HomoloGene: 12045 GeneCards: NCAPH2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,524,780 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,257,029 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; vena cava; ; ganglionic eminence; ; anterior pituitary; ; left uterine tube; ; prefrontal cortex; ; body of pancreas; ; upper lobe of left lung; ; canal of the cervix; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; lip; ; corneal stroma; ; yolk sac; ; superior frontal gyrus; ; morula; ; spermatid; ; thymus; ; neural tube; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; chromatin binding ;
Cellular component	membrane ; chromosome ; nucleus ; nucleoplasm ; cell junction ; intercellular bridge ; condensed chromosome ; condensin complex ;
Biological process	chromosome condensation ; female meiotic nuclear division ; meiotic chromosome condensation ; T cell differentiation in thymus ; chromosome organization ; mitotic sister chromatid separation ; female meiosis chromosome separation ; mitotic chromosome condensation ;
	Sources:Amigo / QuickGO
Orthologs
	29781
	52683
	ENSG00000025770
	ENSMUSG00000008690
	Q6IBW4
	Q8BSP2
	NM_001185011 ; NM_014551 ; NM_152299
	NM_001115132 ; NM_001271600 ; NM_001271601
	NP_001171940 ; NP_055366 ; NP_689512
	NP_001108604 ; NP_001258529 ; NP_001258530
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Condensin-2 complex subunit H2, also known as chromosome-associated protein H2 (CAP-H2) or non-SMC condensin II complex subunit H2 (NCAPH2), is a protein that in humans is encoded by the NCAPH2 gene.^[5] CAP-H2 is a subunit of condensin II, a large protein complex involved in chromosome condensation.

Related Research Articles

<span class="mw-page-title-main">Condensin</span>

Condensins are large protein complexes that play a central role in chromosome assembly and segregation during mitosis and meiosis. Their subunits were originally identified as major components of mitotic chromosomes assembled in Xenopus egg extracts.

SMC complexes represent a large family of ATPases that participate in many aspects of higher-order chromosome organization and dynamics. SMC stands for Structural Maintenance of Chromosomes.

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in high order chromosome organization, including condensation and segregation. SMC-4 protein is commonly associated with the SMC-2 protein, another protein complex within the SMC protein family. SMC-4 dimerizes with SMC-2, creating the flexible and dynamic structure of the condensin holocomplex. An over-expression of the SMC-4 protein is shown to impact carcinogenesis.

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.

Condensin complex subunit 1 also known as chromosome-associated protein D2 (CAP-D2) or non-SMC condensin I complex subunit D2 (NCAPD2) or XCAP-D2 homolog is a protein that in humans is encoded by the NCAPD2 gene. CAP-D2 is a subunit of condensin I, a large protein complex involved in chromosome condensation.

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.

Condensin-2 complex subunit D3 (CAP-D3) also known as non-SMC condensin II complex subunit D3 (NCAPD3) is a protein that, in humans, is encoded by the NCAPD3 gene. CAP-D3 is a subunit of condensin II, a large protein complex involved in chromosome condensation.

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene. CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation. Abnormal expression of NCAPH may be linked to various types of carcinogenesis as a prognostic indicator.

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.

Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene. CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation.

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene. CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis

Integrator complex subunit 9 is a protein that in Humans is encoded by the INTS9 gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.

Structural maintenance of chromosomes protein 2 (SMC-2), also known as chromosome-associated protein E (CAP-E), is a protein that in humans is encoded by the SMC2 gene. SMC2 is part of the SMC protein family and is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation, overall organization. Several studies have demonstrated the necessity of SMC2 for cell division and proliferation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000025770 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008690 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: non-SMC condensin II complex".

Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Ono T, Losada A, Hirano M, et al. (2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi: 10.1016/S0092-8674(03)00724-4 . PMID 14532007.
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Wood AJ, Severson AF, Meyer BJ (2010). "Condensin and cohesin complexity: the expanding repertoire of functions". Nat. Rev. Genet. 11 (6): 391–404. doi:10.1038/nrg2794. PMC 3491780 . PMID 20442714.
Schleiffer A, Kaitna S, Maurer-Stroh S, et al. (2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Mol. Cell. 11 (3): 571–5. doi: 10.1016/S1097-2765(03)00108-4 . PMID 12667442.
Kamatani Y, Matsuda K, Okada Y, et al. (2010). "Genome-wide association study of hematological and biochemical traits in a Japanese population". Nat. Genet. 42 (3): 210–5. doi:10.1038/ng.531. PMID 20139978. S2CID 30790619.
Collins JE, Wright CL, Edwards CA, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000025770 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008690 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: non-SMC condensin II complex".

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NCAPH2

Related Research Articles

References

Further reading