Gem-associated protein 2

Last updated
GEMIN2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GEMIN2 , SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2
External IDs OMIM: 602595 MGI: 1913853 HomoloGene: 37827 GeneCards: GEMIN2
Orthologs
SpeciesHumanMouse
Entrez

8487

66603

Ensembl

ENSG00000092208

ENSMUSG00000060121

UniProt

O14893

Q9CQQ4

RefSeq (mRNA)

NM_001009182
NM_001009183
NM_003616

NM_025656

RefSeq (protein)

NP_001009182
NP_001009183
NP_003607

NP_079932

Location (UCSC) Chr 14: 39.11 – 39.14 Mb Chr 12: 59.01 – 59.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene. [5] [6] [7]

Contents

Interactions

Gem-associated protein 2 has been shown to interact with DDX20 [8] [9] and SMN1. [6] [10] [11]

See also

Related Research Articles

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

Gideon Dreyfuss is an American biochemist who is the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

Survival of motor neuron

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

<i>SMN1</i>

Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.

Small nuclear ribonucleoprotein D1

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Small nuclear ribonucleoprotein D2

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Small nuclear ribonucleoprotein polypeptide E

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

SNRPD3

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

DDX20

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

Small nuclear ribonucleoprotein polypeptide F

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

SNRPB2

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

SNRPG

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

Nucleolar protein, member A1

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.

Gem-associated protein 7

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Gem-associated protein 6

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Gem-associated protein 4

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

Gem-associated protein 5

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

<i>SMN2</i>

Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein in humans.

GEMIN8

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092208 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060121 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–9. doi: 10.1016/S0092-8674(00)80368-2 . PMID   9323130.
  6. 1 2 Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi: 10.1016/S0092-8674(00)80367-0 . PMID   9323129.
  7. ↑ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
  8. ↑ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. ISSN   0890-9369. PMC   155365 . PMID   11914277.
  9. ↑ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN   0021-9525. PMC   2168095 . PMID   10601333.
  10. ↑ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs". J. Cell Sci. 116 (Pt 10): 1905–13. doi: 10.1242/jcs.00409 . ISSN   0021-9533. PMID   12668731.
  11. ↑ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi: 10.1093/hmg/9.13.1977 . ISSN   0964-6906. PMID   10942426.

Further reading

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