NCAPD2

NCAPD2
Identifiers
Aliases	NCAPD2 , CAP-D2, CNAP1, hCAP-D2, non-SMC condensin I complex subunit D2, MCPH21
External IDs	OMIM: 615638; MGI: 1915548; HomoloGene: 6497; GeneCards: NCAPD2; OMA:NCAPD2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,493,356 bp [1] End 6,531,955 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F2- F3 Start 125,144,970 bp [2] End 125,168,664 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence bone marrow cells stromal cell of endometrium granulocyte rectum epithelium of colon gonad Descending thoracic aorta gastric mucosa Top expressed in tail of embryo ventricular zone genital tubercle mandibular prominence yolk sac maxillary prominence thymus spermatocyte epiblast somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding chromatin binding protein binding Cellular component cytoplasm membrane chromosome nucleoplasm condensin complex nuclear chromosome condensed chromosome nucleus condensed chromosome, centromeric region cytosol Biological process mitotic chromosome condensation meiotic chromosome condensation cell division chromosome separation chromosome condensation cell cycle mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9918 68298 Ensembl ENSG00000010292 ENSMUSG00000038252 UniProt Q15021 Q8K2Z4 RefSeq (mRNA) NM_014865 NM_146171 RefSeq (protein) NP_055680 NP_666283 Location (UCSC) Chr 12: 6.49 – 6.53 Mb Chr 6: 125.14 – 125.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Condensin complex subunit 1 also known as chromosome-associated protein D2 (CAP-D2) or non-SMC condensin I complex subunit D2 (NCAPD2) or XCAP-D2 homolog is a protein that in humans is encoded by the NCAPD2 gene. ^{[5] [6] [7]} CAP-D2 is a subunit of condensin I, a large protein complex involved in chromosome condensation.

References

1. GRCh38: Ensembl release 89: ENSG00000010292 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038252 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX   10.1.1.333.6945 . doi:10.1093/dnares/2.4.167. PMID   8590280.
6. Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation". Mol Cell Biol. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC   88774 . PMID   10958694.
7. "Entrez Gene: NCAPD2 non-SMC condensin I complex, subunit D2".

Further reading

• Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC   2168084 . PMID   10601332.
• Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi: 10.1074/jbc.C000873200 . PMID   11136719.
• Ball AR, Schmiesing JA, Zhou C, et al. (2002). "Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7". Mol. Cell. Biol. 22 (16): 5769–81. doi:10.1128/MCB.22.16.5769-5781.2002. PMC   133980 . PMID   12138188.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.