HOXB1

Last updated

HOXB1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HOXB1 , HCFP3, HOX2, HOX2I, Hox-2.9, homeobox B1
External IDs OMIM: 142968; MGI: 96182; HomoloGene: 1615; GeneCards: HOXB1; OMA:HOXB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002144

NM_008266

RefSeq (protein)

NP_002135

NP_032292

Location (UCSC) Chr 17: 48.53 – 48.53 Mb Chr 11: 96.26 – 96.26 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene. [5] [6] [7]

Contents

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [7]

Interactions

HOXB1 has been shown to interact with PBX1. [8] [9]

See also

Related Research Articles

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Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.

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<span class="mw-page-title-main">HOXD13</span> Protein

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<span class="mw-page-title-main">PKNOX1</span> Protein-coding gene in the species Homo sapiens

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB9</span> Protein-coding gene in humans

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

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Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">HOXD9</span> Protein-coding gene in the species Homo sapiens

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Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">PKNOX2</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120094 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018973 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
  7. 1 2 "Entrez Gene: HOXB1 homeobox B1".
  8. Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (March 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC   1170491 . PMID   9482740.
  9. Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (February 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi: 10.1016/S0092-8674(00)80662-5 . PMID   10052460. S2CID   16122785.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.