CEBPD

CEBPD
Identifiers
Aliases	CEBPD , C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
External IDs	OMIM: 116898; MGI: 103573; HomoloGene: 3808; GeneCards: CEBPD; OMA:CEBPD - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q11.21 Start 47,736,913 bp [1] End 47,738,164 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 A2|16 10.09 cM Start 15,705,150 bp [2] End 15,708,895 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium vena cava lower lobe of lung trachea cardia beta cell mucosa of paranasal sinus olfactory bulb cartilage tissue gastric mucosa Top expressed in left lung lobe granulocyte umbilical cord endothelial cell of lymphatic vessel gastrula right lung muscle of thigh carotid body ankle ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific protein homodimerization activity protein heterodimerization activity Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation regulation of transcription by RNA polymerase II fat cell differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated inner ear development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1052 12609 Ensembl ENSG00000221869 ENSMUSG00000071637 UniProt P49716 Q00322 RefSeq (mRNA) NM_005195 NM_007679 RefSeq (protein) NP_005186 NP_031705 Location (UCSC) Chr 8: 47.74 – 47.74 Mb Chr 16: 15.71 – 15.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. ^{[5] [6]}

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. ^[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. ^[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. ^[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation. ^[10]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3. ^[11]

See also

• Ccaat-enhancer-binding proteins

References

1. GRCh38: Ensembl release 89: ENSG00000221869 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071637 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi: 10.1101/gad.5.9.1538 . PMID   1840554.
6. Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi: 10.1101/gad.5.9.1553 . PMID   1884998.
7. "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
8. Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (February 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–1597. doi:10.1038/sj.onc.1208393. PMID   15674331. S2CID   24347537.
9. Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (January 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi: 10.1038/labinvest.2013.127 . PMID   24247561.
10. Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy. Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. PMC   5056990 . PMID   27673562.
11. Choy L, Derynck R (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–9619. doi: 10.1074/jbc.M212259200 . PMID   12524424.

Further reading

• Sladek FM, Darnell JE (April 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–259. doi:10.1016/S0959-437X(05)80282-5. PMID   1638120.
• Kinoshita S, Akira S, Kishimoto T (February 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–1476. Bibcode:1992PNAS...89.1473K. doi: 10.1073/pnas.89.4.1473 . PMC   48473 . PMID   1741402.
• Nagulapalli S, Pongubala JM, Atchison ML (November 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–4338. doi: 10.4049/jimmunol.155.9.4330 . PMID   7594592.
• Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–191. doi:10.1159/000134030. PMID   7789168.
• Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, et al. (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–523. doi:10.1006/geno.1993.1220. PMID   8314590.
• Chen PL, Riley DJ, Chen Y, Lee WH (November 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–2804. doi: 10.1101/gad.10.21.2794 . PMID   8946919.
• Xia C, Cheshire JK, Patel H, Woo P (December 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–1539. doi:10.1016/S1357-2725(97)00083-6. PMID   9570146.
• Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (March 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–6928. doi: 10.1074/jbc.M108075200 . PMID   11741938.
• Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, et al. (December 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–397. doi:10.1006/mcpr.2001.0377. hdl: 11382/3170 . PMID   11851384. S2CID   8215328.
• Gao H, Parkin S, Johnson PF, Schwartz RC (October 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–38837. doi: 10.1074/jbc.M206224200 . PMID   12177065.
• Dearth LR, DeWille J (March 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–11255. doi: 10.1074/jbc.M207930200 . PMID   12554732.
• Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment. 79 (2): 175–185. doi:10.1023/A:1023929504884. PMID   12825852. S2CID   45020949.
• Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (September 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–36965. doi: 10.1074/jbc.M303147200 . PMID   12857754.
• Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (December 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology. 95 (6): 2485–2494. doi:10.1152/japplphysiol.01161.2002. PMID   12937035. S2CID   9817319.
• Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (September 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging. 25 (8): 991–999. doi:10.1016/j.neurobiolaging.2003.10.016. PMID   15212823. S2CID   54232508.
• Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (November 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry. 93 (4): 844–856. doi:10.1002/jcb.20224. PMID   15389878. S2CID   31572695.

External links

• Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser .
• CEBPD+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.