NFYB

NFYB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N1J, 4AWL, 4CSR
Identifiers
Aliases	NFYB , CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDs	OMIM: 189904 MGI: 97317 HomoloGene: 38149 GeneCards: NFYB
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q23.3 Start 104,117,086 bp [1] End 104,138,241 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 40.25 cM Start 82,584,535 bp [2] End 82,599,978 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon endothelial cell right coronary artery seminal vesicula left coronary artery right lung ascending aorta middle temporal gyrus gastric mucosa Top expressed in primitive streak ganglionic eminence saccule maxillary prominence Region I of hippocampus proper otic placode abdominal wall thymus medial ganglionic eminence dentate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding protein binding protein heterodimerization activity DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein-containing complex binding Cellular component protein-DNA complex nucleoplasm CCAAT-binding factor complex nucleus RNA polymerase II transcription regulator complex Biological process positive regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated regulation of cholesterol biosynthetic process cellular response to leukemia inhibitory factor regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4801 18045 Ensembl ENSG00000120837 ENSMUSG00000020248 UniProt P25208 P63139 RefSeq (mRNA) NM_006166 NM_010914 RefSeq (protein) NP_006157 NP_006157.1 NP_035044 Location (UCSC) Chr 12: 104.12 – 104.14 Mb Chr 10: 82.58 – 82.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene. ^{[5] [6]}

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. ^[7]

Interactions

NFYB has been shown to interact with:

• CEBPZ, ^[8]
• CNTN2, ^[9]
• Myc, ^[10] and
• TBP ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000120837 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020248 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID   1774067.
6. Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID   9612081.
7. "Entrez Gene: NFYB nuclear transcription factor Y, beta".
8. Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi: 10.1074/jbc.M101553200 . hdl: 11380/303761 . PMID   11306579.
9. Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC   231848 . PMID   9032250.
10. Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID   11282029.
11. Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC   146709 . PMID   9153318.

Further reading

• Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex". Immunobiology. 198 (1–3): 249–63. doi:10.1016/s0171-2985(97)80045-9. PMID   9442396.
• Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15–27. doi:10.1016/S0378-1119(99)00368-6. PMID   10571030.
• Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D (1992). "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Res. 20 (5): 1087–91. doi:10.1093/nar/20.5.1087. PMC   312095 . PMID   1549471.
• Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D (1992). "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain". J. Biol. Chem. 267 (13): 8984–90. doi: 10.1016/S0021-9258(19)50377-5 . PMID   1577736.
• Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. doi:10.1128/mcb.15.9.5092. PMC   230756 . PMID   7651426.
• Chang ZF, Liu CJ (1994). "Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts". J. Biol. Chem. 269 (27): 17893–8. doi: 10.1016/S0021-9258(17)32393-1 . PMID   8027044.
• Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D (1994). "Dominant negative analogs of NF-YA". J. Biol. Chem. 269 (32): 20340–6. doi: 10.1016/S0021-9258(17)31997-X . PMID   8051128.
• Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC   231848 . PMID   9032250.
• Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC   146709 . PMID   9153318.
• Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)". J. Biol. Chem. 272 (49): 30880–8. doi: 10.1074/jbc.272.49.30880 . PMID   9388234.
• Currie RA (1998). "NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF". J. Biol. Chem. 273 (3): 1430–4. doi: 10.1074/jbc.273.3.1430 . PMID   9430679.
• Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". J. Biol. Chem. 273 (29): 18220–9. doi: 10.1074/jbc.273.29.18220 . PMID   9660784.
• Bemark M, Olsson H, Heinegård D, Leanderson T (1998). "Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription". J. Biol. Chem. 273 (30): 18881–90. doi: 10.1074/jbc.273.30.18881 . PMID   9668064.
• Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F (1999). "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300". J. Biol. Chem. 274 (12): 7623–6. doi: 10.1074/jbc.274.12.7623 . PMID   10075648.
• Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Mol. Cell. Biol. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC   86349 . PMID   11003667.
• Liang F, Schaufele F, Gardner DG (2001). "Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription". J. Biol. Chem. 276 (2): 1516–22. doi: 10.1074/jbc.M006350200 . PMID   11022037.
• Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID   11282029.

External links

• NFYB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook NF-YB

This article incorporates text from the United States National Library of Medicine, which is in the public domain.