Iroquois homeobox factor

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Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes. [1] [2] The loci were named for the flies carrying mutations in one of these genes, which are devoid of all bristles in the lateral part of the notum, leaving only a median stripe of bristles, similar to the Iroquois tribes which shaved all but a medial stripe of hairs on the head. [3]

Human genes that encode Iroquois homeobox factors include: [2]

References

  1. ↑ Gómez-Skarmeta JL, Modolell J (August 2002). "Iroquois genes: genomic organization and function in vertebrate neural development". Curr. Opin. Genet. Dev. 12 (4): 403–8. doi:10.1016/S0959-437X(02)00317-9. PMID   12100884.
  2. 1 2 Kerner P, Ikmi A, Coen D, Vervoort M (2009). "Evolutionary history of the iroquois/Irx genes in metazoans". BMC Evol. Biol. 9 (1) 74. Bibcode:2009BMCEE...9...74K. doi: 10.1186/1471-2148-9-74 . PMC   2674049 . PMID   19368711.
  3. ↑ Leyns L, Gómez-Skarmeta JL, Dambly-Chaudière C (September 1996). "iroquois: a prepattern gene that controls the formation of bristles on the thorax ofDrosophila". Mech. Dev. 59 (1): 63–72. doi: 10.1016/0925-4773(96)00577-1 . PMID   8892233. S2CID   8144286.
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