MXD3

MXD3
Identifiers
Aliases	MXD3 , BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDs	OMIM: 609450; MGI: 104987; HomoloGene: 32333; GeneCards: MXD3; OMA:MXD3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 177,301,461 bp [1] End 177,312,757 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 B1|13 29.8 cM Start 55,472,981 bp [2] End 55,477,636 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone granulocyte monocyte blood ganglionic eminence spleen bone marrow mucosa of transverse colon trabecular bone gastric mucosa Top expressed in lumbar spinal ganglion fossa ascending aorta internal carotid artery aortic valve thymus crypt of lieberkuhn of small intestine external carotid artery condyle ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein dimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus RNA polymerase II transcription regulator complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83463 17121 Ensembl ENSG00000213347 ENSMUSG00000021485 UniProt Q9BW11 Q80US8 RefSeq (mRNA) NM_031300 NM_001142935 NM_001394986 NM_001394987 NM_016662 RefSeq (protein) NP_001136407 NP_112590 NP_112590.1 NP_057871 Location (UCSC) Chr 5: 177.3 – 177.31 Mb Chr 13: 55.47 – 55.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5. ^{[5] [6]}

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex. ^[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle. ^[7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000213347 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021485 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC   394680 . PMID   8521822.
6. "Entrez Gene: MXD3 MAX dimerization protein 3".
7. Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC   1223166 . PMID   12444919.
8. Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7) e38508. Bibcode:2012PLoSO...738508B. doi: 10.1371/journal.pone.0038508 . PMC   3393725 . PMID   22808009.