MXD3

Last updated
MXD3
Identifiers
Aliases MXD3 , BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDs OMIM: 609450 MGI: 104987 HomoloGene: 32333 GeneCards: MXD3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031300
NM_001142935
NM_001394986
NM_001394987

NM_016662

RefSeq (protein)

NP_001136407
NP_112590
NP_112590.1

NP_057871

Location (UCSC) Chr 5: 177.3 – 177.31 Mb Chr 13: 55.47 – 55.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5. [5] [6]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex. [6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle. [7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels. [8]

Related Research Articles

Basic helix–loop–helix Protein structural motif

A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

N-Myc Protein-coding gene in the species Homo sapiens

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

TCF3 Protein-coding gene in the species Homo sapiens

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

ID2 Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

MAX (gene) Protein-coding gene in the species Homo sapiens

MAX is a gene that in humans encodes the MAX transcription factor.

ID3 (gene) Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

MXI1

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.

HES1 Protein-coding gene in the species Homo sapiens

Transcription factor HES1 is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.

RFX1

MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.

MYCL

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.

MXD1

MAD protein is a protein that in humans is encoded by the MXD1 gene.

<i>ERF</i> (gene)

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.

<i>MLX</i> (gene) Protein-coding gene in the species Homo sapiens

Max-like protein X is a protein that in humans is encoded by the MLX gene.

MXD4

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.

MNT (gene) Protein-coding gene in the species Homo sapiens

MNT is a Max-binding protein that is encoded by the MNT gene

TFAP4

Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

BHLHE41 Protein-coding gene in the species Homo sapiens

"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.

NKX6-1

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213347 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021485 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC   394680 . PMID   8521822.
  6. 1 2 "Entrez Gene: MXD3 MAX dimerization protein 3".
  7. Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC   1223166 . PMID   12444919.
  8. Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. Bibcode:2012PLoSO...738508B. doi: 10.1371/journal.pone.0038508 . PMC   3393725 . PMID   22808009.