Zinc finger protein 165

ZNF165
Identifiers
Aliases	ZNF165 , CT53, LD65, ZSCAN7, zinc finger protein 165
External IDs	OMIM: 600834; HomoloGene: 122143; GeneCards: ZNF165; OMA:ZNF165 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 28,080,568 bp [1] End 28,089,563 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm gonad testicle amniotic fluid left testis right testis mucosa of sigmoid colon islet of Langerhans body of pancreas rectum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7718 n/a Ensembl ENSG00000197279 n/a UniProt P49910 Q53Z40 n/a RefSeq (mRNA) NM_003447 NM_001376491 NM_001376492 NM_001376493 NM_001376494 n/a RefSeq (protein) NP_003438 NP_001363420 NP_001363421 NP_001363422 NP_001363423 NP_003438.1 n/a Location (UCSC) Chr 6: 28.08 – 28.09 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 165 is a protein that in humans is encoded by the ZNF165 gene. ^{[3] [4]}

Function

This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. ^[4]

Interactions

Zinc finger protein 165 has been shown to interact with Ewing sarcoma breakpoint region 1 ^[5] and DVL2. ^[5]

See also

• Zinc finger

References

1. GRCh38: Ensembl release 89: ENSG00000197279 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Tirosvoutis KN, Divane A, Jones M, Affara NA (Jan 1996). "Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis". Genomics. 28 (3): 485–90. doi:10.1006/geno.1995.1178. PMID   7490084.
4. "Entrez Gene: ZNF165 zinc finger protein 165".
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Lee PL, Gelbart T, West C, Adams M, Blackstone R, Beutler E (1997). "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain". Genomics. 43 (2): 191–201. doi:10.1006/geno.1997.4806. PMID   9244436.
• Paoloni-Giacobino A, Kern I, Rumpler Y, Djlelati R, Morris MA, Dahoun SP (2001). "Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility". Clin. Genet. 58 (4): 324–8. doi:10.1034/j.1399-0004.2000.580411.x. PMID   11076058. S2CID   19063057.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• ZNF165+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.