DVL2

DVL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2REY, 3CBX, 3CBY, 3CBZ, 3CC0, 4WIP
Identifiers
Aliases	DVL2 , dishevelled segment polarity protein 2
External IDs	OMIM: 602151; MGI: 106613; HomoloGene: 20927; GeneCards: DVL2; OMA:DVL2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 7,225,342 bp [1] End 7,234,517 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B3|11 42.96 cM Start 69,891,421 bp [2] End 69,903,127 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone stromal cell of endometrium left ovary ectocervix right ovary body of uterus right hemisphere of cerebellum canal of the cervix anterior pituitary ganglionic eminence Top expressed in yolk sac ventricular zone granulocyte epiblast superior frontal gyrus neural layer of retina spermatocyte genital tubercle tail of embryo dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein domain specific binding frizzled binding protein self-association protein binding identical protein binding protein kinase binding Cellular component membrane clathrin-coated endocytic vesicle plasma membrane apical part of cell clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical Wnt signaling pathway positive regulation of protein phosphorylation intracellular signal transduction positive regulation of protein tyrosine kinase activity heart morphogenesis canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of DNA-binding transcription factor activity transcription by RNA polymerase II hippo signaling positive regulation of transcription, DNA-templated multicellular organism development positive regulation of GTPase activity protein complex oligomerization cochlea morphogenesis convergent extension involved in neural plate elongation negative regulation of canonical Wnt signaling pathway segmentation convergent extension involved in organogenesis positive regulation of canonical Wnt signaling pathway neural tube closure heart development Wnt signaling pathway outflow tract morphogenesis canonical Wnt signaling pathway segment specification positive regulation of JUN kinase activity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly membrane organization positive regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1856 13543 Ensembl ENSG00000004975 ENSMUSG00000020888 UniProt O14641 Q60838 RefSeq (mRNA) NM_004422 NM_007888 RefSeq (protein) NP_004413 NP_031914 Location (UCSC) Chr 17: 7.23 – 7.23 Mb Chr 11: 69.89 – 69.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. ^{[5] [6]}

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. ^[6]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165, ^[7] DAB2 ^[8] and Arrestin beta 1. ^[9]

See also

• Dishevelled

References

1. GRCh38: Ensembl release 89: ENSG00000004975 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020888 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID   8662242. S2CID   39619679.
6. "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
7. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
8. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN   0261-4189. PMC   162138 . PMID   12805222.
9. Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. Bibcode:2001PNAS...9814889C. doi: 10.1073/pnas.211572798 . ISSN   0027-8424. PMC   64954 . PMID   11742073.

Further reading

• Pizzuti A, Amati F, Calabrese G, et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum. Mol. Genet. 5 (7): 953–8. doi: 10.1093/hmg/5.7.953 . PMID   8817329.
• Klingensmith J, Yang Y, Axelrod JD, et al. (1997). "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2". Mech. Dev. 58 (1–2): 15–26. doi: 10.1016/S0925-4773(96)00549-7 . PMID   8887313. S2CID   16004832.
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics. 42 (2): 302–10. doi: 10.1006/geno.1997.4713 . PMID   9192851.
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi: 10.1074/jbc.275.4.2399 . PMID   10644691.
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–7. doi: 10.1074/jbc.M909107199 . PMID   10806215.
• Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 275 (32): 25008–14. doi: 10.1074/jbc.M002491200 . PMID   10829020.
• Chen W, Hu LA, Semenov MV, et al. (2002). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. Bibcode:2001PNAS...9814889C. doi: 10.1073/pnas.211572798 . PMC   64954 . PMID   11742073.
• Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell. 107 (7): 843–54. doi: 10.1016/S0092-8674(01)00614-6 . PMID   11779461. S2CID   16894557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Habas R, Dawid IB, He X (2003). "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation". Genes Dev. 17 (2): 295–309. doi:10.1101/gad.1022203. PMC   195976 . PMID   12533515.
• Chen W, ten Berge D, Brown J, et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science. 301 (5638): 1391–4. Bibcode:2003Sci...301.1391C. doi:10.1126/science.1082808. PMID   12958364. S2CID   34975427.
• Wong CK, Luo W, Deng Y, et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". J. Biol. Chem. 279 (38): 39366–73. doi: 10.1074/jbc.M404598200 . PMID   15262978.
• Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–13. doi: 10.1074/jbc.M408675200 . PMID   15456783.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Zhang L, Gao X, Wen J, et al. (2006). "Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation". J. Biol. Chem. 281 (13): 8607–12. doi: 10.1074/jbc.M600274200 . PMID   16446366.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.