MTF1

MTF1
Identifiers
Aliases	MTF1 , MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
External IDs	OMIM: 600172 MGI: 101786 HomoloGene: 4347 GeneCards: MTF1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.3 Start 37,809,574 bp [1] End 37,859,592 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D2.2|4 57.91 cM Start 124,695,897 bp [2] End 124,743,593 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte cavity of mouth bronchial epithelial cell nipple internal globus pallidus gums monocyte bone marrow cells blood spongy bone Top expressed in spermatid spermatocyte seminiferous tubule secondary oocyte internal carotid artery motor neuron lacrimal gland retinal pigment epithelium external carotid artery ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding protein binding histone acetyltransferase binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm Biological process response to cadmium ion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II response to metal ion response to oxidative stress transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II central nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4520 17764 Ensembl ENSG00000188786 ENSMUSG00000028890 UniProt Q14872 Q07243 RefSeq (mRNA) NM_005955 NM_008636 RefSeq (protein) NP_005946 NP_032662 Location (UCSC) Chr 1: 37.81 – 37.86 Mb Chr 4: 124.7 – 124.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene. ^{[5] [6]}

Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000188786 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028890 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Aug 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Research. 22 (15): 3167–73. doi:10.1093/nar/22.15.3167. PMC   310292 . PMID   8065932.
6. "Entrez Gene: MTF1 metal-regulatory transcription factor 1".

Further reading

• Westin G, Schaffner W (Dec 1988). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene". The EMBO Journal. 7 (12): 3763–70. doi:10.1002/j.1460-2075.1988.tb03260.x. PMC   454951 . PMID   3208749.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Chen X, Chu M, Giedroc DP (Sep 1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry. 38 (39): 12915–25. doi:10.1021/bi9913000. PMID   10504263.
• Otsuka F, Okugaito I, Ohsawa M, Iwamatsu A, Suzuki K, Koizumi S (Jul 2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (2–3): 330–40. doi:10.1016/s0167-4781(00)00110-x. PMID   11004505.
• Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W (Jul 2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". The Journal of Biological Chemistry. 276 (27): 25487–95. doi: 10.1074/jbc.M009154200 . PMID   11306562.
• Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH (Jun 2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription". The Journal of Biological Chemistry. 277 (23): 20438–45. doi: 10.1074/jbc.M110631200 . PMID   11923282.
• Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST (Jul 2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". The Journal of Biological Chemistry. 278 (28): 26216–26. doi: 10.1074/jbc.M302887200 . PMC   2365495 . PMID   12716893.
• Saydam N, Steiner F, Georgiev O, Schaffner W (Aug 2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological Chemistry. 278 (34): 31879–83. doi: 10.1074/jbc.M302138200 . PMID   12805380.
• Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP (Feb 2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". The Journal of Biological Chemistry. 279 (6): 4515–22. doi: 10.1074/jbc.M308924200 . PMID   14610091.
• Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W (Jul 2004). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biological Chemistry. 385 (7): 597–603. doi: 10.1515/BC.2004.074 . PMID   15318808. S2CID   34611525.
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID   15735762. S2CID   25970893.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• MTF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.