ZNF239

ZNF239
Identifiers
Aliases	ZNF239 , HOK-2, MOK2, zinc finger protein 239
External IDs	OMIM: 601069 MGI: 1306812 HomoloGene: 68480 GeneCards: ZNF239
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q11.21 Start 43,556,344 bp [1] End 43,574,618 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F1|6 55.62 cM Start 117,862,100 bp [2] End 117,873,291 bp [2]
RNA expression pattern Bgee Top expressed in testicle left coronary artery urinary bladder neocortex prefrontal cortex endometrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity DNA binding GO:0001948 protein binding metal ion binding nucleic acid binding GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific RNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8187	22685
Ensembl	ENSG00000196793	ENSMUSG00000042097
UniProt	Q16600	P24399
RefSeq (mRNA)	NM_001099282 NM_001099283 NM_001099284 NM_005674 NM_001324347 NM_001324348 NM_001324349 NM_001324350 NM_001324351 NM_001324352 NM_001324353	NM_001001792 NM_008616 NM_001360938
RefSeq (protein)	NP_001092752 NP_001092753 NP_001092754 NP_001311276 NP_001311277 NP_001311278 NP_001311279 NP_001311280 NP_001311281 NP_001311282 NP_005665	NP_001001792 NP_032642 NP_001347867
Location (UCSC)	Chr 10: 43.56 – 43.57 Mb	Chr 6: 117.86 – 117.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene. ^{[5] [6] [7]}

Function

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures. ^{[7] [8]}

Interactions

ZNF239 has been shown to interact with LMNA. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000196793 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042097 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Arranz V, Kress M, Ernoult-Lange M (Jan 1996). "Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19". Mammalian Genome. 7 (1): 77–8. doi:10.1007/s003359900020. PMID   8903737. S2CID   36851320.
6. Ernoult-Lange M, Arranz V, Le Coniat M, Berger R, Kress M (Dec 1995). "Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins". Journal of Molecular Evolution. 41 (6): 784–94. Bibcode:1995JMolE..41..784E. doi:10.1007/bf00173158. PMID   8587123. S2CID   22955858.
7. "Entrez Gene: ZNF239 zinc finger protein 239".
8. Arranz V, Harper F, Florentin Y, Puvion E, Kress M, Ernoult-Lange M (Apr 1997). "Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains". Molecular and Cellular Biology. 17 (4): 2116–26. doi:10.1128/mcb.17.4.2116. PMC   232059 . PMID   9121460.
9. Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002). "In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C". Nucleic Acids Research. 30 (21): 4634–42. doi:10.1093/nar/gkf587. PMC   135794 . PMID   12409453.

Further reading

• Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002). "In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C". Nucleic Acids Research. 30 (21): 4634–42. doi:10.1093/nar/gkf587. PMC   135794 . PMID   12409453.

\* Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• ZNF239+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.