Y box binding protein 1

YBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H95
Identifiers
Aliases	YBX1 , BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	OMIM: 154030 MGI: 99146 HomoloGene: 88707 GeneCards: YBX1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.2 Start 42,682,418 bp [1] End 42,703,805 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.1 Start 119,135,178 bp [2] End 119,151,801 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon gastrocnemius muscle skeletal muscle tissue left ventricle stromal cell of endometrium smooth muscle tissue popliteal artery appendix left coronary artery Top expressed in primitive streak abdominal wall medial ganglionic eminence seminiferous tubule maxillary prominence sciatic nerve somite Paneth cell interventricular septum crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding RNA binding nucleic acid binding GTPase binding double-stranded DNA binding single-stranded DNA binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm CRD-mediated mRNA stability complex nuclear membrane intracellular membrane-bounded organelle U12-type spliceosomal complex nucleoplasm extracellular region cytoplasmic stress granule extracellular exosome nucleus histone pre-mRNA 3'end processing complex cytosol ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA splicing, via spliceosome regulation of transcription, DNA-templated mRNA processing transcription by RNA polymerase II protein localization to cytoplasmic stress granule transcription, DNA-templated positive regulation of cell division positive regulation of transcription by RNA polymerase II in utero embryonic development RNA splicing negative regulation of striated muscle cell differentiation negative regulation of transcription by RNA polymerase II Notch signaling pathway cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4904 22608 Ensembl ENSG00000065978 ENSMUSG00000028639 UniProt P67809 P62960 RefSeq (mRNA) NM_004559 NM_011732 RefSeq (protein) NP_004550 NP_035862 Location (UCSC) Chr 1: 42.68 – 42.7 Mb Chr 4: 119.14 – 119.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. ^[5]

Clinical significance

YBX1 is a potential drug target in cancer therapy. ^[6] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. ^[6] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions

Y box binding protein 1 has been shown to interact with:

• ANKRD2, ^[7]
• CTCF, ^[8]
• P53, ^{[7] [9]}
• PCNA, ^[10]
• RBBP6, ^[11] and
• SFRS9. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000065978 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028639 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: YBX1 Y box binding protein 1".
6. Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 (Suppl 2): 187–90. doi: 10.1007/s00292-008-1030-2 . PMID   18773210.
7. Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID   15136035.
8. Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi: 10.1074/jbc.M001538200 . PMID   10906122.
9. Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene. 19 (54): 6194–202. doi: 10.1038/sj.onc.1204029 . PMID   11175333.
10. Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID   9927044.
11. Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID   18851979.
12. Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi: 10.1074/jbc.M212518200 . PMID   12604611.

Further reading

• Kolluri R, Torrey TA, Kinniburgh AJ (1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif". Nucleic Acids Res. 20 (1): 111–6. doi:10.1093/nar/20.1.111. PMC   5356827 . PMID   1738588.
• Kolluri R, Kinniburgh AJ (1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein". Nucleic Acids Res. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMC   328725 . PMID   1891370.
• Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID   2977358.
• Didier DK, Schiffenbauer J, Woulfe SL, et al. (1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. Bibcode:1988PNAS...85.7322D. doi: 10.1073/pnas.85.19.7322 . PMC   282178 . PMID   3174636.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID   7628487.
• Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. doi:10.1128/mcb.15.9.5092. PMC   230756 . PMID   7651426.
• Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. Bibcode:1995PNAS...92.1087C. doi: 10.1073/pnas.92.4.1087 . PMC   42642 . PMID   7862639.
• Horwitz EM, Maloney KA, Ley TJ (1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes". J. Biol. Chem. 269 (19): 14130–9. doi: 10.1016/S0021-9258(17)36764-9 . PMID   8188694.
• Kashanchi F, Duvall JF, Dittmer J, et al. (1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression". J. Virol. 68 (1): 561–5. doi:10.1128/JVI.68.1.561-565.1994. PMC   236322 . PMID   8254772.
• Makino Y, Ohga T, Toh S, et al. (1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter". Nucleic Acids Res. 24 (10): 1873–8. doi:10.1093/nar/24.10.1873. PMC   145870 . PMID   8657568.
• Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC   146158 . PMID   8871564.
• Koike K, Uchiumi T, Ohga T, et al. (1998). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation". FEBS Lett. 417 (3): 390–4. doi: 10.1016/S0014-5793(97)01296-9 . PMID   9409758. S2CID   24656107.
• Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–7. doi:10.1016/S0378-1119(97)00570-2. PMID   9461420.
• Sawaya BE, Khalili K, Amini S (1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat". J. Gen. Virol. 79. ( Pt 2) (2): 239–46. doi: 10.1099/0022-1317-79-2-239 . PMID   9472608.
• Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription". J. Biol. Chem. 273 (49): 32957–65. doi: 10.1074/jbc.273.49.32957 . PMID   9830047.
• Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID   9927044.
• Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells". Mol. Cell. Biol. 19 (4): 2712–23. doi:10.1128/mcb.19.4.2712. PMC   84064 . PMID   10082537.
• Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi: 10.1074/jbc.274.20.14238 . PMID   10318844.
• Safak M, Gallia GL, Ansari SA, Khalili K (1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen". J. Virol. 73 (12): 10146–57. doi:10.1128/JVI.73.12.10146-10157.1999. PMC   113067 . PMID   10559330.
• Ansari SA, Safak M, Gallia GL, et al. (1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity". J. Gen. Virol. 80. ( Pt 10) (10): 2629–38. doi: 10.1099/0022-1317-80-10-2629 . PMID   10573156.
• Basaki Y, Hosoi F, Oda Y, et al. (2007). "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells". Oncogene. 26 (19): 2736–46. doi: 10.1038/sj.onc.1210084 . PMID   17072343.

External links

• YBX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.