SFRS9

SRSF9
Identifiers
Aliases	SRSF9 , SFRS9, SRp30c, serine/arginine-rich splicing factor 9, serine and arginine rich splicing factor 9
External IDs	OMIM: 601943 MGI: 104896 HomoloGene: 20819 GeneCards: SRSF9
Gene location (Human)
Chr.	Chromosome 12 (human) [1]
End	120,469,748 bp [1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse) [2]
End	115,333,080 bp [2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding ; • nucleic acid binding ; • RNA binding ; • protein domain specific binding ;
Cellular component	• nucleolus ; • cell nucleus ; • nucleoplasm ; • nuclear speck ;
Biological process	• mRNA splicing, via spliceosome ; • termination of RNA polymerase II transcription ; • mRNA processing ; • negative regulation of mRNA splicing, via spliceosome ; • mRNA splice site selection ; • mRNA export from nucleus ; • mRNA 3'-end processing ; • response to alkaloid ; • RNA export from nucleus ; • RNA splicing ; • response to toxic substance ; • regulation of alternative mRNA splicing, via spliceosome ; • mRNA cis splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	8683
	108014
	ENSG00000111786
	ENSMUSG00000029538
	Q13242
	Q9D0B0
	NM_003769
	NM_025573
	NP_003760
	NP_079849
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 13, 2020

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.^[5]

Interactions

SFRS9 has been shown to interact with Y box binding protein 1 ^[6] and NOL3.^[7]

Related Research Articles

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111786 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029538 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9".
↑ Raffetseder, Ute; Frye Björn; Rauen Thomas; Jürchott Karsten; Royer Hans-Dieter; Jansen Petra Lynen; Mertens Peter R (May 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi: 10.1074/jbc.M212518200 . ISSN 0021-9258. PMID 12604611.
↑ Stoss, O; Schwaiger F W; Cooper T A; Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi: 10.1074/jbc.274.16.10951 . ISSN 0021-9258. PMID 10196175.

Screaton GR, Cáceres JF, Mayeda A, et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518 . PMID 7556075.
Nayler O, Strätling W, Bourquin JP, et al. (1998). "SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements". Nucleic Acids Res. 26 (15): 3542–9. doi:10.1093/nar/26.15.3542. PMC 147731 . PMID 9671816.
Yuan Y; Li DM; Sun H (1998). "PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes". J. Biol. Chem. 273 (32): 20347–53. doi: 10.1074/jbc.273.32.20347 . PMID 9685386.
Petersen-Mahrt SK, Estmer C, Ohrmalm C, et al. (1999). "The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation". EMBO J. 18 (4): 1014–24. doi:10.1093/emboj/18.4.1014. PMC 1171193 . PMID 10022843.
Stoss O; Schwaiger FW; Cooper TA; Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi: 10.1074/jbc.274.16.10951 . PMID 10196175.
Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499 . PMID 10823932.
Stoss O, Olbrich M, Hartmann AM, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites". J. Biol. Chem. 276 (12): 8665–73. doi: 10.1074/jbc.M006851200 . PMID 11118435.
Denegri M, Chiodi I, Corioni M, et al. (2002). "Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors". Mol. Biol. Cell. 12 (11): 3502–14. doi:10.1091/mbc.12.11.3502. PMC 60271 . PMID 11694584.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi: 10.1093/hmg/11.5.577 . PMID 11875052.
Simard MJ; Chabot B (2002). "SRp30c is a repressor of 3' splice site utilization". Mol. Cell. Biol. 22 (12): 4001–10. doi:10.1128/MCB.22.12.4001-4010.2002. PMC 133842 . PMID 12024014.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Raffetseder U, Frye B, Rauen T, et al. (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi: 10.1074/jbc.M212518200 . PMID 12604611.
Xu Q; Leung DY; Kisich KO (2003). "Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils". J. Biol. Chem. 278 (29): 27112–8. doi: 10.1074/jbc.M300824200 . PMID 12738786.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616 . PMID 14559993.
Kondo S, Yamamoto N, Murakami T, et al. (2004). "Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA". Genes Cells. 9 (2): 121–30. doi:10.1111/j.1356-9597.2004.00709.x. PMID 15009090. S2CID 22248867.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wang Y, Wang J, Gao L, et al. (2005). "Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1". J. Biol. Chem. 280 (14): 14230–9. doi: 10.1074/jbc.M413846200 . PMID 15695522.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi: 10.1038/nature04569 . PMID 16541075.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111786 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029538 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9".

[pmid12604611-6] Raffetseder, Ute; Frye Björn; Rauen Thomas; Jürchott Karsten; Royer Hans-Dieter; Jansen Petra Lynen; Mertens Peter R (May 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi: 10.1074/jbc.M212518200 . ISSN 0021-9258. PMID 12604611.

[pmid10196175-7] Stoss, O; Schwaiger F W; Cooper T A; Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi: 10.1074/jbc.274.16.10951 . ISSN 0021-9258. PMID 10196175.

SFRS9

Contents

Interactions

Related Research Articles

References

Further reading