POU4F2

Last updated
POU4F2
Identifiers
Aliases POU4F2 , BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs OMIM: 113725; MGI: 102524; HomoloGene: 20959; GeneCards: POU4F2; OMA:POU4F2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004575

NM_138944

RefSeq (protein)

NP_004566

NP_620394

Location (UCSC) Chr 4: 146.64 – 146.64 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene. [4] [5]

Contents

Function

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM] [5]

Interactions

POU4F2 has been shown to interact with Estrogen receptor alpha. [6]

See also

Related Research Articles

<span class="mw-page-title-main">Transcription factor</span> Protein that regulates the rate of DNA transcription

In molecular biology, a transcription factor (TF) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are approximately 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome.

<span class="mw-page-title-main">Oct-4</span> Mammalian protein found in Homo sapiens

Oct-4, also known as POU5F1, is a protein that in humans is encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.

<span class="mw-page-title-main">Estrogen receptor alpha</span> Protein-coding gene in the species Homo sapiens

Estrogen receptor alpha (ERα), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1.

Oct-2 also known as POU domain, class 2, transcription factor 2 is a protein that in humans is encoded by the POU2F2 gene.

<span class="mw-page-title-main">Transcription factor Jun</span> Mammalian protein found in Homo sapiens

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BRN-3 is a group of related transcription factors in the POU family. They are also known as class 4 POU domain homeobox proteins.

<span class="mw-page-title-main">Non-POU domain-containing octamer-binding protein</span> Protein-coding gene in the species Homo sapiens

Non-POU domain-containing octamer-binding protein (NonO) is a protein that in humans is encoded by the NONO gene.

<span class="mw-page-title-main">RNA-binding protein EWS</span> Human protein and coding gene

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family.

<span class="mw-page-title-main">MTA2</span> Protein-coding gene in the species Homo sapiens

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

<span class="mw-page-title-main">POU3F2</span> Protein-coding gene in the species Homo sapiens

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.

<span class="mw-page-title-main">POU4F1</span> Protein-coding gene in the species Homo sapiens

POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene.

<span class="mw-page-title-main">DACH1</span> Protein-coding gene in the species Homo sapiens

Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.

<span class="mw-page-title-main">BCAR3</span> Protein-coding gene in the species Homo sapiens

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.

<span class="mw-page-title-main">POU3F1</span> Protein-coding gene in the species Homo sapiens

POU domain, class 3, transcription factor 1 is a protein that in humans is encoded by the POU3F1 gene.

<span class="mw-page-title-main">EGR3</span> Protein-coding gene in humans

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.

<span class="mw-page-title-main">HOXC10</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.

<span class="mw-page-title-main">POU4F3</span> Protein-coding gene in the species Homo sapiens

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene. It's a member of BRN-3 group, also known as POU family class 4.

<span class="mw-page-title-main">TFAP2C</span> Protein-coding gene in the species Homo sapiens

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.

<span class="mw-page-title-main">FOXA1</span> Protein-coding gene in the species Homo sapiens

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.

<span class="mw-page-title-main">ATPase Domain 3B</span>

ATPase Domain 3B (ATAD3B) is a protein that in humans is encoded by the ATAD3B gene. ATAD3 is part of the AAA protein family. The function of ATAD3B is not yet well understood by the scientific community. In humans the gene is located at 1p36.33.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000151615 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC   309696 . PMID   8332509.
  5. 1 2 "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
  6. Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC   108815 . PMID   9448000.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.