IRF2

IRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRF, 1IRG, 2IRF
Identifiers
Aliases	IRF2 , IRF-2, interferon regulatory factor 2
External IDs	OMIM: 147576; MGI: 96591; HomoloGene: 1659; GeneCards: IRF2; OMA:IRF2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q35.1 Start 184,385,702 bp [1] End 184,474,558 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B1.1 Start 47,192,767 bp [2] End 47,300,493 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood Achilles tendon granulocyte olfactory zone of nasal mucosa appendix spleen lymph node rectum right adrenal cortex Top expressed in granulocyte blood left colon spleen left lobe of liver mesenteric lymph nodes muscle of thigh thymus duodenum tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus focal adhesion nucleoplasm cytosol Biological process interferon-gamma-mediated signaling pathway cell population proliferation blood coagulation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II type I interferon signaling pathway transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3660 16363 Ensembl ENSG00000168310 ENSMUSG00000031627 UniProt P14316 P23906 RefSeq (mRNA) NM_002199 NM_008391 RefSeq (protein) NP_002190 NP_032417 Location (UCSC) Chr 4: 184.39 – 184.47 Mb Chr 8: 47.19 – 47.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene. ^[5]

Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. ^[6]

See also

• IRF1
• Interferon regulatory factors

Interactions

IRF2 has been shown to interact with BRD7, ^[7] EP300 ^[8] and PCAF. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000168310 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031627 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID   2475256. S2CID   2033941.
6. "Entrez Gene: IRF2 interferon regulatory factor 2".
7. Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID   11025449. S2CID   22932901.
8. Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi: 10.1074/jbc.M101707200 . PMID   11304541.
9. Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. doi:10.1128/MCB.19.3.1810. PMC   83974 . PMID   10022868.

Further reading

• Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie. 80 (8–9): 641–50. doi:10.1016/S0300-9084(99)80017-0. PMID   9865486.
• Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. doi: 10.1016/S0300-9084(99)80018-2 . PMID   9865487.
• Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T (1989). "Sequence of a cDNA coding for human IRF-2". Nucleic Acids Res. 17 (20): 8372. doi:10.1093/nar/17.20.8372. PMC   334978 . PMID   2813069.
• Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system". Mol. Cell. Biol. 14 (2): 1500–9. doi:10.1128/MCB.14.2.1500. PMC   358505 . PMID   7507207.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. doi: 10.1074/jbc.270.22.13063 . PMID   7768900.
• Cha Y, Deisseroth AB (1994). "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region". J. Biol. Chem. 269 (7): 5279–87. doi: 10.1016/S0021-9258(17)37685-8 . PMID   8106512.
• Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2". Science. 259 (5097): 971–4. Bibcode:1993Sci...259..971H. doi:10.1126/science.8438157. PMID   8438157. S2CID   41036818.
• Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K (1996). "Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells". J. Neuroimmunol. 63 (2): 157–62. doi:10.1016/0165-5728(95)00140-9. PMID   8550813. S2CID   53166594.
• Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo". J. Cell. Biochem. 66 (2): 175–83. doi:10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N. PMID   9213219. S2CID   34485265.
• Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. doi:10.1128/MCB.19.3.1810. PMC   83974 . PMID   10022868.
• Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. PMID   10102295.
• Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE (1999). "Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays". Ann. Neurol. 46 (3): 425–8. doi:10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O. PMID   10482277. S2CID   85574347.
• Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia". Leuk. Lymphoma. 35 (5–6): 507–11. doi:10.1080/10428199909169615. PMID   10609788.
• Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID   11025449. S2CID   22932901.
• Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5". J. Viral Hepat. 8 (2): 103–10. doi:10.1046/j.1365-2893.2001.00273.x. PMID   11264730. S2CID   55595193.
• Masumi A, Ozato K (2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi: 10.1074/jbc.M101707200 . PMID   11304541.

External links

• Media related to Interferon regulatory factor-2, IRF-2 at Wikimedia Commons
• IRF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.