SOCS5

Last updated
SOCS5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SOCS5 , CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs OMIM: 607094; MGI: 2385459; HomoloGene: 10495; GeneCards: SOCS5; OMA:SOCS5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144949
NM_014011

NM_019654

RefSeq (protein)

NP_054730
NP_659198

NP_062628

Location (UCSC) Chr 2: 46.7 – 46.78 Mb Chr 17: 87.42 – 87.45 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene. [5] [6] [7]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171150 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037104 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
  7. 1 2 "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".

Further reading