SOCS7

SOCS7
Identifiers
Aliases	SOCS7 , NAP4, NCKAP4, suppressor of cytokine signaling 7
External IDs	OMIM: 608788 MGI: 2651588 HomoloGene: 16331 GeneCards: SOCS7
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 38,351,844 bp [1] End 38,405,593 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 97,253,261 bp [2] End 97,289,368 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellum cerebellar cortex cerebellar hemisphere ganglionic eminence sural nerve islet of Langerhans skeletal muscle tissue superior frontal gyrus prefrontal cortex gastrocnemius muscle Top expressed in seminiferous tubule secondary oocyte cerebellar vermis triceps brachii muscle nucleus accumbens spermatocyte cingulate gyrus olfactory tubercle Region I of hippocampus proper digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component plasma membrane membrane nucleus cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process insulin receptor signaling pathway regulation of growth negative regulation of signal transduction intracellular signal transduction cerebral cortex radially oriented cell migration layer formation in cerebral cortex fat cell differentiation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway radial glia guided migration of Purkinje cell negative regulation of receptor signaling pathway via JAK-STAT biological process regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30837 192157 Ensembl ENSG00000274229 ENSG00000274211 ENSMUSG00000038485 UniProt O14512 Q8VHQ2 RefSeq (mRNA) NM_014598 NM_138657 RefSeq (protein) NP_055413 NP_619598 Location (UCSC) Chr 17: 38.35 – 38.41 Mb Chr 11: 97.25 – 97.29 Mb PubMed search [3] [4]
Wikidata
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Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene. ^{[5] [6] [7]}

Model organisms

Socs7 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Abnormal [8]
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Salmonella infection	Normal [9]
Citrobacter infection	Normal [10]
All tests and analysis from [11] [12]

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7^{tm1a(EUCOMM)Wtsi [13] [14]} was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. ^{[15] [16] [17]}

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. ^{[11] [18]} Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia. ^[11]

Interactions

SOCS7 has been shown to interact with NCK1. ^[5]

References

1. ENSG00000274211 GRCh38: Ensembl release 89: ENSG00000274229, ENSG00000274211 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID   9344857.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
7. "Entrez Gene: SOCS7 suppressor of cytokine signaling 7".
8. "Body temperature data for Socs7". Wellcome Trust Sanger Institute.
9. "Salmonella infection data for Socs7". Wellcome Trust Sanger Institute.
10. "Citrobacter infection data for Socs7". Wellcome Trust Sanger Institute.
11. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
12. Mouse Resources Portal, Wellcome Trust Sanger Institute.
13. "International Knockout Mouse Consortium".
14. "Mouse Genome Informatics".
15. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
16. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID   21677718. S2CID   39281705.
17. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
18. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224 . PMC   3218837 . PMID   21722353.

Further reading

• Cooney RN (Feb 2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway". Shock. 17 (2): 83–90. doi: 10.1097/00024382-200202000-00001 . PMID   11837794. S2CID   40940132.
• Wormald S, Hilton DJ (Jan 2004). "Inhibitors of cytokine signal transduction" (PDF). The Journal of Biological Chemistry. 279 (2): 821–4. doi: 10.1074/jbc.R300030200 . PMID   14607831. S2CID   3469978.
• Fujimoto M, Naka T (Dec 2003). "Regulation of cytokine signaling by SOCS family molecules". Trends in Immunology. 24 (12): 659–66. doi:10.1016/j.it.2003.10.008. PMID   14644140.
• Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA (Jan 1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 114–9. Bibcode:1998PNAS...95..114H. doi: 10.1073/pnas.95.1.114 . PMC   18144 . PMID   9419338.
• Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID   10969179. S2CID   23752435.
• Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS (Jul 2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Molecular and Cellular Biology. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC   133908 . PMID   12052866.
• Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL (Aug 2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Experimental Cell Research. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID   15242778.
• Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A (Apr 2005). "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation". The Journal of Biological Chemistry. 280 (14): 13817–23. doi: 10.1074/jbc.M411596200 . PMID   15677474.
• Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB (Sep 2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans". The Journal of Clinical Investigation. 115 (9): 2462–71. doi:10.1172/JCI23853. PMC   1190369 . PMID   16127460.
• Kremer BE, Adang LA, Macara IG (Sep 2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell. 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMC   2085444 . PMID   17803907.