SOCS6

SOCS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VIF
Identifiers
Aliases	SOCS6 , CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6
External IDs	OMIM: 605118; MGI: 1924885; HomoloGene: 3120; GeneCards: SOCS6; OMA:SOCS6 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q22.2 Start 70,289,045 bp [1] End 70,330,199 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E4 Start 88,683,348 bp [2] End 88,945,605 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus biceps brachii Skeletal muscle tissue of rectus abdominis jejunal mucosa oral cavity mucosa of colon mucosa of sigmoid colon Skeletal muscle tissue of biceps brachii right ventricle caput epididymis Top expressed in otic vesicle otic placode zygote saccule secondary oocyte pineal gland yolk sac intercostal muscle soleus muscle medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm immunological synapse cytosol phosphatidylinositol 3-kinase complex Biological process regulation of growth defense response proteasomal protein catabolic process receptor signaling pathway via JAK-STAT negative regulation of signal transduction intracellular signal transduction negative regulation of T cell activation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT post-translational protein modification regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9306 54607 Ensembl ENSG00000170677 ENSMUSG00000056153 UniProt O14544 Q9JLY0 RefSeq (mRNA) NM_004232 NM_016387 NM_018821 RefSeq (protein) NP_004223 NP_061291 Location (UCSC) Chr 18: 70.29 – 70.33 Mb Chr 18: 88.68 – 88.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene. ^{[5] [6] [7]}

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000170677 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056153 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID   9344848.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
7. "Entrez Gene: SOCS6 suppressor of cytokine signaling 6".

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
• Mooney RA, Senn J, Cameron S, et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance". J. Biol. Chem. 276 (28): 25889–93. doi: 10.1074/jbc.M010579200 . PMID   11342531.
• Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC   133908 . PMID   12052866.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi: 10.1074/jbc.M313381200 . PMID   14707129.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Bayle J, Lopez S, Iwaï K, et al. (2006). "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins". FEBS Lett. 580 (11): 2609–14. doi: 10.1016/j.febslet.2006.03.093 . PMID   16643902. S2CID   44648698.
• Hwang MN, Ha TH, Park J, et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation". Biochem. Biophys. Res. Commun. 354 (1): 184–9. doi:10.1016/j.bbrc.2006.12.175. PMID   17210122.
• Hwang MN, Min CH, Kim HS, et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels". Biochem. Biophys. Res. Commun. 360 (2): 333–8. doi:10.1016/j.bbrc.2007.06.062. PMID   17603019.