GTF2F2

GTF2F2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBY, 1F3U, 2BBY, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	GTF2F2 , BTF4, RAP30, TF2F2, TFIIF, general transcription factor IIF subunit 2
External IDs	OMIM: 189969 MGI: 1915955 HomoloGene: 37884 GeneCards: GTF2F2
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.12-q14.13 Start 45,120,510 bp [1] End 45,284,893 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 76,134,377 bp [2] End 76,248,305 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon skin of abdomen gastrocnemius muscle tibial nerve left ventricle monocyte Left adrenal gland rectum oocyte Top expressed in morula uterus mirror spermatid cervix spermatocyte seminiferous tubule corneal stroma maxillary prominence abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding helicase activity protein binding hydrolase activity ATP binding Cellular component microtubule cytoskeleton nucleoplasm transcription factor TFIIF complex nucleus transcription preinitiation complex Biological process mRNA splicing, via spliceosome regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter transcription, DNA-templated positive regulation of viral transcription transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway positive regulation of transcription elongation from RNA polymerase II promoter RNA metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2963 68705 Ensembl ENSG00000188342 ENSMUSG00000067995 UniProt P13984 Q8R0A0 RefSeq (mRNA) NM_004128 NM_026816 RefSeq (protein) NP_004119 NP_081092 Location (UCSC) Chr 13: 45.12 – 45.28 Mb Chr 14: 76.13 – 76.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene. ^{[5] [6]}

Interactions

GTF2F2 has been shown to interact with POLR2E ^[7] and HTATSF1. ^[8]

See also

• Transcription Factor II F

References

1. GRCh38: Ensembl release 89: ENSG00000188342 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067995 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID   8162052.
6. "Entrez Gene: GTF2F2 general transcription factor IIF, polypeptide 2, 38kDa".
7. Wei W, Dorjsuren D, Lin Y, Qin W, Nomura T, Hayashi N, Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. 276 (15): 12266–73. doi: 10.1074/jbc.M009634200 . PMID   11278533.
8. Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC   84462 . PMID   10454543.

Further reading

• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi: 10.1101/gad.6.4.655 . PMID   1559613.
• Horikoshi M, Fujita H, Wang J, Takada R, Roeder RG (1991). "Nucleotide and amino acid sequence of RAP30". Nucleic Acids Res. 19 (19): 5436. doi:10.1093/nar/19.19.5436. PMC   328912 . PMID   1840667.
• Sopta M, Burton ZF, Greenblatt J (1989). "Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II". Nature. 341 (6241): 410–4. Bibcode:1989Natur.341..410S. doi:10.1038/341410a0. PMID   2477704. S2CID   4321793.
• Sopta M, Carthew RW, Greenblatt J (1985). "Isolation of three proteins that bind to mammalian RNA polymerase II". J. Biol. Chem. 260 (18): 10353–60. doi: 10.1016/S0021-9258(17)39255-4 . PMID   3860504.
• Tan S, Aso T, Conaway RC, Conaway JW (1994). "Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase II". J. Biol. Chem. 269 (41): 25684–91. doi: 10.1016/S0021-9258(18)47303-6 . PMID   7929273.
• Yonaha M, Aso T, Kobayashi Y, Vasavada H, Yasukochi Y, Weissman SM, Kitajima S (1993). "Domain structure of a human general transcription initiation factor, TFIIF". Nucleic Acids Res. 21 (2): 273–9. doi:10.1093/nar/21.2.273. PMC   309103 . PMID   8441635.
• Tang H, Sun X, Reinberg D, Ebright RH (1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1119–24. Bibcode:1996PNAS...93.1119T. doi: 10.1073/pnas.93.3.1119 . PMC   40041 . PMID   8577725.
• Martin ML, Lieberman PM, Curran T (1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF". Mol. Cell. Biol. 16 (5): 2110–8. doi:10.1128/mcb.16.5.2110. PMC   231198 . PMID   8628277.
• Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi: 10.1074/jbc.271.20.11703 . PMID   8662660.
• Dubrovskaya V, Lavigne AC, Davidson I, Acker J, Staub A, Tora L (1996). "Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex". EMBO J. 15 (14): 3702–12. doi:10.1002/j.1460-2075.1996.tb00740.x. PMC   452026 . PMID   8758937.
• Rowlands JC, McEwan IJ, Gustafsson JA (1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors". Mol. Pharmacol. 50 (3): 538–48. PMID   8794892.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID   8934526. S2CID   4278432.
• Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". J. Biochem. 121 (2): 389–96. doi:10.1093/oxfordjournals.jbchem.a021600. PMID   9089417.
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC   232028 . PMID   9121429.
• McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485–90. Bibcode:1997PNAS...94.8485M. doi: 10.1073/pnas.94.16.8485 . PMC   22967 . PMID   9238003.
• Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression". Biochemistry. 36 (34): 10451–62. doi:10.1021/bi971008x. PMID   9265625.
• Liang G, Hai T (1997). "Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein". J. Biol. Chem. 272 (38): 24088–95. doi: 10.1074/jbc.272.38.24088 . PMID   9295363.
• Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". J. Biol. Chem. 273 (31): 19866–76. doi: 10.1074/jbc.273.31.19866 . PMID   9677423.

External links

• GTF2F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.