HTATSF1

HTATSF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIT
Identifiers
Aliases	HTATSF1 , TAT-SF1, TATSF1, dJ196E23.2, HIV-1 Tat specific factor 1
External IDs	OMIM: 300346; MGI: 1919709; HomoloGene: 40950; GeneCards: HTATSF1; OMA:HTATSF1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq26.3 Start 136,497,079 bp [1] End 136,512,346 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A6 Start 56,098,943 bp [2] End 56,112,543 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Skeletal muscle tissue of rectus abdominis pituitary gland germinal epithelium internal globus pallidus epithelium of nasopharynx ganglionic eminence tendon of biceps brachii vastus lateralis muscle anterior pituitary Top expressed in pituitary gland saccule vas deferens fossa condyle otic vesicle ankle otic placode triceps brachii muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component U2-type spliceosomal complex nucleus U2 snRNP nucleoplasm Biological process regulation of transcription by RNA polymerase II viral genome replication regulation of DNA-templated transcription, elongation regulation of transcription, DNA-templated transcription, DNA-templated mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27336 72459 Ensembl ENSG00000102241 ENSMUSG00000067873 UniProt O43719 Q8BGC0 RefSeq (mRNA) NM_001163280 NM_014500 NM_028242 NM_029371 RefSeq (protein) NP_001156752 NP_055315 NP_082518 NP_083647 Location (UCSC) Chr X: 136.5 – 136.51 Mb Chr X: 56.1 – 56.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene. ^{[5] [6]}

Function

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication. ^[6]

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins. ^[7] It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2. ^[7]

Interactions

HTATSF1 has been shown to interact with SUPT5H ^[8] and GTF2F2. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000102241 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067873 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou Q, Sharp PA (November 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
6. "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".
7. Corsini NS, Peer AM, Moeseneder P, Roiuk M, Burkard TR, Theussl HC, Moll I, Knoblich JA (April 2018). "Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation". Cell Stem Cell. 22 (4): 543–558.e12. doi: 10.1016/j.stem.2018.03.002 . ISSN   1934-5909. PMID   29625069.
8. Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp P A (September 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN   0270-7306. PMC   84462 . PMID   10454543.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhou Q, Chen D, Pierstorff E, Luo K (1998). "Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages". EMBO J. 17 (13): 3681–91. doi:10.1093/emboj/17.13.3681. PMC   1170704 . PMID   9649438.
• Yan D, Perriman R, Igel H, et al. (1998). "CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif". Mol. Cell. Biol. 18 (9): 5000–9. doi:10.1128/MCB.18.9.5000. PMC   109085 . PMID   9710584.
• Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC   317190 . PMID   9765201.
• Parada CA, Roeder RG (1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". EMBO J. 18 (13): 3688–701. doi:10.1093/emboj/18.13.3688. PMC   1171446 . PMID   10393184.
• Kim JB, Yamaguchi Y, Wada T, et al. (1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC   84462 . PMID   10454543.
• Fong YW, Zhou Q (2000). "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 20 (16): 5897–907. doi:10.1128/MCB.20.16.5897-5907.2000. PMC   86067 . PMID   10913173.
• Suñé C, Goldstrohm AC, Peng J, et al. (2000). "An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation". Virology. 274 (2): 356–66. doi: 10.1006/viro.2000.0480 . PMID   10964778.
• Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi: 10.1016/S1074-7613(01)00158-3 . PMID   11420046.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID   11780068. S2CID   1518837.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhou BY, He JJ (2004). "Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein". Neurosci. Lett. 359 (3): 155–8. doi:10.1016/j.neulet.2004.02.012. PMID   15050687. S2CID   3048557.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. CiteSeerX   10.1.1.567.1545 . doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC   522232 . PMID   15485897.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhou M, Deng L, Lacoste V, et al. (2004). "Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription". J. Virol. 78 (24): 13522–33. doi:10.1128/JVI.78.24.13522-13533.2004. PMC   533906 . PMID   15564463.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Missé D, Gajardo J, Oblet C, et al. (2005). "Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression". AIDS. 19 (9): 897–905. doi:10.1097/01.aids.0000171403.07995.92. PMID   15905670. S2CID   23688259.