IFI35

Last updated
IFI35
Identifiers
Aliases IFI35 , IFP35, interferon induced protein 35
External IDs OMIM: 600735 MGI: 1917360 HomoloGene: 4040 GeneCards: IFI35
Orthologs
SpeciesHumanMouse
Entrez

3430

70110

Ensembl

ENSG00000068079

ENSMUSG00000010358

UniProt

P80217

Q9D8C4

RefSeq (mRNA)

NM_005533
NM_001330230

NM_027320

RefSeq (protein)

NP_001317159
NP_005524

NP_081596

Location (UCSC) Chr 17: 43.01 – 43.01 Mb Chr 11: 101.34 – 101.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene. [5]

Contents

Interactions

IFI35 has been shown to interact with NMI [6] and BATF. [7]

Related Research Articles

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Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). STAT2 sequence identity between mouse and human is only 68%.

RHOB

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.

TCF3 Protein-coding gene in the species Homo sapiens

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PIK3R2

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NOD1 Protein receptor that recognizes bacterial molecules and stimulates an immune reaction

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene. It recognizes bacterial molecules and stimulates an immune reaction.

ISG15

Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.

RAP1GAP

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.

Nucleolin Protein

Nucleolin is a protein that in humans is encoded by the NCL gene.

Interferon gamma receptor 1

Interferon gamma receptor 1 (IFNGR1) also known as CD119, is a protein that in humans is encoded by the IFNGR1 gene.

TANK-binding kinase 1

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

IFI16

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

LIMK2

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.

RFC3

Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.

N-myc-interactor

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

IFI27

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

CITED2

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.

CACYBP Protein-coding gene in the species Homo sapiens

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.

<i>BATF</i> (gene) Protein-coding gene in the species Homo sapiens

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.

MX2 Protein-coding gene in the species Homo sapiens

Interferon-induced GTP-binding protein MX2/MXB is a protein that in humans is encoded by the MX2 gene.

ISG20

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000068079 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010358 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: IFI35 interferon-induced protein 35".
  6. ↑ Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L (November 2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". The Journal of Biological Chemistry. 275 (46): 36278–84. doi: 10.1074/jbc.M006975200 . PMID   10950963.
  7. ↑ Wang X, Johansen LM, Tae HJ, Taparowsky EJ (December 1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochemical and Biophysical Research Communications. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID   8954125.

Further reading

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