NKX2-3

NKX2-3
Identifiers
Aliases	NKX2-3 , CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727 MGI: 97348 HomoloGene: 17061 GeneCards: NKX2-3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,536,524 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,604,331 bp
RNA expression pattern
	Top expressed in
	spleen; ; transverse colon; ; duodenum; ; sural nerve; ; minor salivary gland; ; jejunal mucosa; ; cecum; ; rectum; ; appendix; ; pylorus;
	Top expressed in
	Hindgut; ; yolk sac; ; Stomodeum; ; duodenum; ; pharyngeal pouch; ; ileum; ; tongue; ; jejunum; ; colon; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding ; DNA binding ; molecular function ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA-binding transcription factor activity ;
Cellular component	nucleus ; cellular component ;
Biological process	leukocyte homeostasis ; CD4-positive, alpha-beta T cell differentiation ; post-embryonic digestive tract morphogenesis ; regulation of transcription, DNA-templated ; plasma cell differentiation ; spleen development ; post-embryonic development ; transcription, DNA-templated ; macrophage differentiation ; mucosa-associated lymphoid tissue development ; odontogenesis of dentin-containing tooth ; gland morphogenesis ; regulation of cell population proliferation ; immune response ; B cell differentiation ; Peyer's patch development ; digestive tract development ; lymph node development ; triglyceride metabolic process ; leukocyte migration ; positive regulation of transcription by RNA polymerase II ; biological process ; cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	159296
	18089
	ENSG00000119919
	ENSMUSG00000044220
	Q8TAU0
	P97334
	NM_145285
	NM_008699
	NP_660328
	NP_032725
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.^[5]^[6]^[7]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.^[7]

Related Research Articles

PDX1, also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.

Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2-5 gene.

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.

Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

Secretoglobin family 3A member 2 is a protein that in humans is encoded by the SCGB3A2 gene.

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe (bap) in Drosophila and therefore also known as Bapx1. The protein encoded by this gene is a homeodomain containing transcription factor.

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.

tinman, or tin is an Nk2-homeobox containing transcription factor first isolated in Drosophila flies. The human homolog is the Nkx2-5 gene. tinman is expressed in the precardiac mesoderm and is responsible for the differentiation, proliferation, and specification of cardiac progenitor cells. This gene is named after the character Tin Woodman who lacks a heart, as flies with nonfunctional tinman genes have cardiac deformities.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119919 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044220 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.
↑ Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi: 10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z . PMID 9142493.
1 2 "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Harvey RP (1996). "NK-2 homeobox genes and heart development". Dev. Biol. 178 (2): 203–16. doi: 10.1006/dbio.1996.0212 . PMID 8812123.
Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen". Development. 126 (10): 2215–25. doi:10.1242/dev.126.10.2215. PMID 10207146.
Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi: 10.1074/jbc.M105826200 . PMID 11457859.
Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119919 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044220 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1346742-5] Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.

[pmid9142493-6] Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi: 10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z . PMID 9142493.

[entrez-7] 1 2 "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

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NKX2-3

Related Research Articles

References

Further reading