NKX2-3

NKX2-3
Identifiers
Aliases	NKX2-3 , CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727; MGI: 97348; HomoloGene: 17061; GeneCards: NKX2-3; OMA:NKX2-3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.2 Start 99,532,942 bp [1] End 99,536,524 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 36.67 cM Start 43,600,764 bp [2] End 43,604,331 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon spleen transverse colon duodenum sural nerve minor salivary glands jejunal mucosa mucosa of transverse colon cecum rectum Top expressed in Hindgut migratory enteric neural crest cell yolk sac Stomodeum buccopharyngeal membrane duodenum pharyngeal pouch ileum tongue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding molecular function DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity Cellular component nucleus cellular component Biological process leukocyte homeostasis CD4-positive, alpha-beta T cell differentiation post-embryonic digestive tract morphogenesis regulation of transcription, DNA-templated plasma cell differentiation spleen development post-embryonic development transcription, DNA-templated macrophage differentiation mucosa-associated lymphoid tissue development odontogenesis of dentin-containing tooth gland morphogenesis regulation of cell population proliferation immune response B cell differentiation Peyer's patch development digestive tract development lymph node development triglyceride metabolic process leukocyte migration positive regulation of transcription by RNA polymerase II biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 159296 18089 Ensembl ENSG00000119919 ENSMUSG00000044220 UniProt Q8TAU0 P97334 RefSeq (mRNA) NM_145285 NM_008699 RefSeq (protein) NP_660328 NP_032725 Location (UCSC) Chr 10: 99.53 – 99.54 Mb Chr 19: 43.6 – 43.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene. ^{[5] [6] [7]}

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000119919 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044220 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID   1346742. S2CID   22766848.
6. Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi: 10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z . PMID   9142493.
7. "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Further reading

• Harvey RP (1996). "NK-2 homeobox genes and heart development". Dev. Biol. 178 (2): 203–16. doi: 10.1006/dbio.1996.0212 . PMID   8812123.
• Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen". Development. 126 (10): 2215–25. doi:10.1242/dev.126.10.2215. PMID   10207146.
• Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi: 10.1074/jbc.M105826200 . PMID   11457859.
• Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID   12141427.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.