SALL2

SALL2
Identifiers
Aliases	SALL2 , COLB, HSAL2, Sal-2, ZNF795, p150(Sal2), spalt-like transcription factor 2, spalt like transcription factor 2
External IDs	OMIM: 602219 MGI: 1354373 HomoloGene: 9269 GeneCards: SALL2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 21,521,080 bp [1] End 21,537,216 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C2 Start 52,548,629 bp [2] End 52,566,219 bp [2]
RNA expression pattern Bgee Top expressed in cerebellum cerebellar vermis cerebellar hemisphere hypothalamus embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity sequence-specific DNA binding DNA binding GO:0001948 protein binding metal ion binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0032403 protein-containing complex binding Cellular component NuRD complex nucleus Biological process eye development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II neural tube development signal transduction transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6297	50524
Ensembl	ENSG00000165821	ENSMUSG00000049532
UniProt	Q9Y467	Q9QX96
RefSeq (mRNA)	NM_001291446 NM_001291447 NM_005407 NM_001364564	NM_001244916 NM_015772
RefSeq (protein)	NP_001278375 NP_001278376 NP_005398 NP_001351493	NP_001231845 NP_056587
Location (UCSC)	Chr 14: 21.52 – 21.54 Mb	Chr 14: 52.55 – 52.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000165821 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049532 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kohlhase J, Schuh R, Dowe G, Kühnlein RP, Jäckle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar HA, Köhler A, Müller U, Raab-Vetter M, Burkhardt E, Engel W, Stick R (December 1996). "Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt". Genomics. 38 (3): 291–8. doi:10.1006/geno.1996.0631. PMID   8975705.
6. "Entrez Gene: SALL2 sal-like 2 (Drosophila)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Sweetman D, Münsterberg A (May 2006). "The vertebrate spalt genes in development and disease" (PDF). Developmental Biology. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID   16545361.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
• Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M (October 2003). "Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology". The American Journal of Pathology. 163 (4): 1449–56. doi:10.1016/S0002-9440(10)63502-X. PMC   1868308 . PMID   14507652.
• Li D, Tian Y, Ma Y, Benjamin T (May 2004). "p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP)". Molecular and Cellular Biology. 24 (9): 3885–93. doi:10.1128/MCB.24.9.3885-3893.2004. PMC   387742 . PMID   15082782.