KLF13

Last updated
KLF13
Identifiers
Aliases KLF13 , BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13
External IDs OMIM: 605328; MGI: 1354948; HomoloGene: 32288; GeneCards: KLF13; OMA:KLF13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

51621

50794

Ensembl

ENSG00000169926
ENSG00000275746

ENSMUSG00000052040

UniProt

Q9Y2Y9

Q9JJZ6

RefSeq (mRNA)

NM_001302461
NM_015995

NM_021366

RefSeq (protein)

NP_001289390
NP_057079

NP_067341

Location (UCSC) Chr 15: 31.33 – 31.44 Mb Chr 7: 63.54 – 63.59 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene. [5] [6] [7]

Contents

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes. [8] Ghrelin levels also positively correlated with methylation levels of cg07814318. [8] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively. [8]

Function

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes. [5] [9]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1. [7] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression. [7] [10] [11] [12] [13] [14] [15]

Interactions

KLF13 has been shown to interact with CREB-binding protein, [16] Heat shock protein 47 [16] and PCAF. [16]

See also

Related Research Articles

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<span class="mw-page-title-main">GLIS1</span> Protein-coding gene

Glis1 is gene encoding a Krüppel-like protein of the same name whose locus is found on Chromosome 1p32.3. The gene is enriched in unfertilised eggs and embryos at the one cell stage and it can be used to promote direct reprogramming of somatic cells to induced pluripotent stem cells, also known as iPS cells. Glis1 is a highly promiscuous transcription factor, regulating the expression of numerous genes, either positively or negatively. In organisms, Glis1 does not appear to have any directly important functions. Mice whose Glis1 gene has been removed have no noticeable change to their phenotype.

Glutamate-rich protein 4 is encoded by the gene ERICH4 and can be otherwise known as chromosome 19 open reading frame 69 (C19orf69). ERICH4 is highly conserved in mammals and exhibits overexpression in tissues of the kidneys, terminal ileum, and duodenum. The function of ERICH4 has yet to be well understood by the scientific community but is suggested to contribute to immune inflammatory responses.

References

  1. 1 2 3 ENSG00000275746 GRCh38: Ensembl release 89: ENSG00000169926, ENSG00000275746 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052040 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: KLF13 Kruppel-like factor 13".
  6. ↑ Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. Bibcode:1999NYASA.880...94C. doi: 10.1111/j.1749-6632.1999.tb09513.x . PMID   10415854. S2CID   7618847.
  7. 1 2 3 Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi: 10.1016/S1074-7613(00)80010-2 . PMID   10023774.
  8. 1 2 3 Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB (14 Feb 2017). "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels". Int J Obes (Lond). 43 (6): 990–994. doi:10.1038/ijo.2017.43. PMID   28194012. S2CID   52835570.
  9. ↑ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID   11087666.
  10. ↑ Song A, Nikolcheva T, Krensky AM (Oct 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID   11138780. S2CID   30184294.
  11. ↑ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (Jul 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation. 110 (1): 119–26. doi:10.1172/JCI15336. PMC   151028 . PMID   12093895.
  12. ↑ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (Aug 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry. 277 (33): 30055–65. doi: 10.1074/jbc.M204278200 . PMID   12050170.
  13. ↑ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology. 178 (9): 5496–504. doi:10.4049/jimmunol.178.9.5496. PMC   2664650 . PMID   17442931.
  14. ↑ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC   2674583 . PMID   17513757.
  15. ↑ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (Jan 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC   1800668 . PMID   17074812.
  16. 1 2 3 Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi: 10.1074/jbc.M108826200 . PMC   2808425 . PMID   11748222.

Further reading

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