Germ cell nuclear factor

Last updated
NR6A1
Identifiers
Aliases NR6A1 , CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR, nuclear receptor subfamily 6 group A member 1
External IDs OMIM: 602778 MGI: 1352459 HomoloGene: 36308 GeneCards: NR6A1
Orthologs
SpeciesHumanMouse
Entrez

2649

14536

Ensembl

ENSG00000148200

ENSMUSG00000063972

UniProt

Q15406

Q64249

RefSeq (mRNA)

NM_001278546
NM_001489
NM_033334
NM_033335

NM_001159548
NM_001159549
NM_010264

RefSeq (protein)

NP_001265475
NP_001480
NP_201591
NP_201591.2

NP_001153020
NP_001153021
NP_034394

Location (UCSC) Chr 9: 124.52 – 124.77 Mb Chr 2: 38.61 – 38.82 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene. [5] [6] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

Contents

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation. [7]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants. [8]

In cells undergoing homologous recombination during meiosis, DNA intermediates are processed as an essential step in the exchange of information between parental homologous chromosomes. In eukaryotes the RTR complex, which consists of a type IA topoisomerase, a RecQ helicase and the structural protein RMI1, is employed in processing DNA recombination intermediates. [9]

Related Research Articles

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<span class="mw-page-title-main">SPRR1B</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000148200 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063972 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation". Journal of Molecular Endocrinology. 18 (2): 167–76. doi:10.1677/jme.0.0180167. PMID   9134503.
  6. ↑ Süsens U, Borgmeyer U (Dec 1996). "Characterization of the human germ cell nuclear factor gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1309 (3): 179–82. doi:10.1016/s0167-4781(96)00157-1. PMID   8982251.
  7. ↑ Zechel C (Dec 2005). "The germ cell nuclear factor (GCNF)". Molecular Reproduction and Development. 72 (4): 550–6. doi: 10.1002/mrd.20377 . PMID   16155958. S2CID   39315293.
  8. ↑ "Entrez Gene: NR6A1 nuclear receptor subfamily 6, group A, member 1".
  9. ↑ Knoll A, Schröpfer S, Puchta H. The RTR complex as caretaker of genome stability and its unique meiotic function in plants. Front Plant Sci. 2014 Feb 12;5:33. doi: 10.3389/fpls.2014.00033. PMID: 24575106; PMCID: PMC3921566

Further reading

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