PHF16

JADE3
Identifiers
Aliases	JADE3 , JADE-3, PHF16, jade family PHD finger 3
External IDs	OMIM: 300618 MGI: 2148019 HomoloGene: 40981 GeneCards: JADE3
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.3 Start 46,912,276 bp [1] End 47,061,242 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A1.3 Start 20,291,927 bp [2] End 20,386,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis placenta seminal vesicula ganglionic eminence secondary oocyte Left adrenal gland body of pancreas visceral pleura germinal epithelium Top expressed in superior cervical ganglion yolk sac medullary collecting duct cumulus cells primitive streak ovary islet of Langerhans urothelium hand ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component histone acetyltransferase complex Biological process histone H4-K16 acetylation histone H4-K8 acetylation histone H4-K12 acetylation histone H3 acetylation histone H4-K5 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9767 382207 Ensembl ENSG00000102221 ENSMUSG00000037315 UniProt Q92613 Q6IE82 RefSeq (mRNA) NM_014735 NM_001077445 NM_001289684 NM_199317 RefSeq (protein) NP_001070913 NP_055550 NP_001276613 NP_955021 NP_001393168 NP_001393169 NP_001393170 Location (UCSC) Chr X: 46.91 – 47.06 Mb Chr X: 20.29 – 20.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene. ^{[5] [6]}

This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000102221 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037315 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (Apr 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID   11944989.
6. "Entrez Gene: PHF16 PHD finger protein 16".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• Szelei J, Soto AM, Geck P, et al. (2000). "Identification of human estrogen-inducible transcripts that potentially mediate the apoptotic response in breast cancer". J. Steroid Biochem. Mol. Biol. 72 (3–4): 89–102. doi:10.1016/S0960-0760(00)00025-X. PMID   10775800. S2CID   25912630.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tzouanacou E, Tweedie S, Wilson V (2003). "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development". Mol. Cell. Biol. 23 (23): 8553–2. doi:10.1128/MCB.23.23.8553-8562.2003. PMC   262661 . PMID   14612400.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• PHF16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.