ZNF146

ZNF146
Identifiers
Aliases	ZNF146 , OZF, zinc finger protein 146
External IDs	OMIM: 601505; MGI: 1347092; HomoloGene: 117615; GeneCards: ZNF146; OMA:ZNF146 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.12 Start 36,214,602 bp [1] End 36,238,771 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 29,860,694 bp [2] End 29,869,175 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura epithelium of nasopharynx amniotic fluid lactiferous duct germinal epithelium visceral pleura tibia inferior ganglion of vagus nerve subthalamic nucleus pericardium Top expressed in ventricular zone genital tubercle tail of embryo neural layer of retina yolk sac muscle of thigh ganglionic eminence dentate gyrus of hippocampal formation granule cell superior frontal gyrus otic placode More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding zinc ion binding heparin binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleolus nucleus cytosol Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7705 26465 Ensembl ENSG00000167635 ENSMUSG00000037029 UniProt Q15072 Q8BQN6 RefSeq (mRNA) NM_001099638 NM_001099639 NM_007145 NM_011980 NM_001357557 RefSeq (protein) NP_001093108 NP_001093109 NP_009076 NP_036110 NP_001344486 Location (UCSC) Chr 19: 36.21 – 36.24 Mb Chr 7: 29.86 – 29.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene. ^{[5] [6] [7]}

See also

• Zinc finger

References

1. GRCh38: Ensembl release 89: ENSG00000167635 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037029 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Blottiere L, Apiou F, Ferbus D, Guenzi C, Dutrillaux B, Prosperi MT, Goubin G (Oct 1999). "Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene". Cytogenet Cell Genet. 85 (3–4): 297–300. doi:10.1159/000015316 (inactive 2024-07-25). PMID   10449921. S2CID   39015999.
6. Hayes H, Le Chalony C, Goubin G, Mercier D, Payen E, Bignon C, Kohno K (Jul 1996). "Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map". Cytogenet Cell Genet. 72 (4): 342–6. doi:10.1159/000134218. PMID   8641144.
7. "Entrez Gene: ZNF146 zinc finger protein 146".

Further reading

• Le Chalony C, Prospéri MT, Haluza R, et al. (1994). "The OZF gene encodes a protein consisting essentially of zinc finger motifs". J. Mol. Biol. 236 (2): 399–404. doi:10.1006/jmbi.1994.1151. PMID   8107129.
• Ferbus D, Le Chalony C, Prospéri MT, et al. (1996). "Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs". Eur. J. Biochem. 236 (3): 991–5. doi: 10.1111/j.1432-1033.1996.00991.x . PMID   8665923.
• Ferbus D, Fléchon A, Muleris M, et al. (1999). "Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas". Int. J. Cancer. 80 (3): 369–72. doi: 10.1002/(SICI)1097-0215(19990129)80:3<369::AID-IJC6>3.0.CO;2-Y . PMID   9935176.
• Pibouin L, Villaudy J, Prospéri MT, Goubin G (2001). "Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains". Cytogenet. Cell Genet. 92 (1–2): 80–4. doi:10.1159/000056873 (inactive 2024-07-25). PMID   11306801. S2CID   23868551.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ferbus D, Bovin C, Validire P, Goubin G (2003). "The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer". J. Pathol. 200 (2): 177–82. doi:10.1002/path.1337. PMID   12754738. S2CID   477806.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID   15838871. S2CID   10264323.
• Antoine K, Prosperi MT, Ferbus D, et al. (2005). "A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo". Mol. Cell. Biochem. 271 (1–2): 215–23. doi:10.1007/s11010-005-6417-2. PMID   15881673. S2CID   10800223.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• ZNF146+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.