MNX1

Last updated
MNX1
Identifiers
Aliases MNX1 , HB9, HLXB9, HOXHB9, SCRA1, motor neuron and pancreas homeobox 1
External IDs OMIM: 142994 MGI: 109160 HomoloGene: 21137 GeneCards: MNX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005515
NM_001165255

NM_019944

RefSeq (protein)

NP_001158727
NP_005506

NP_064328

Location (UCSC) Chr 7: 156.99 – 157.01 Mb Chr 5: 29.68 – 29.68 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene. [5]

Contents

Clinical significance

Mutations in the MNX1 gene are associated with Currarino syndrome. [6] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. [7]

Related Research Articles

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Currarino syndrome Medical condition

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N-acetylgalactosamine-6-sulfatase is an enzyme that, in humans, is encoded by the GALNS gene.

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HNF1B Mammalian protein found in Homo sapiens

HNF1 homeobox B, also known as HNF1B or transcription factor 2 (TCF2), is a human gene.

EYA1

Eyes absent homolog 1 is a protein that in humans is encoded by the EYA1 gene.

GJB3

Gap junction beta-3 protein (GJB3), also known as connexin 31 (Cx31) — is a protein that in humans is encoded by the GJB3 gene.

HOXD13

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

HOXA13

Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene.

HOXB9

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

DLX3

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

HOXD9

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

HOXD4

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

HOXD11

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.

<i>HLX</i> (gene) Protein-coding gene in the species Homo sapiens

Homeobox Protein HB24 is a protein that in humans is encoded by the HLX gene.

SIX5

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.

HOXD12

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.

HOXD1

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

DLX6

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.

HOXA2

Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130675 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001566 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: HLXB9 homeobox HB9".
  6. Merello E, De Marco P, Ravegnani M, Riccipetitoni G, Cama A, Capra V (2013). "Novel MNX1 mutations and clinical analysis of familial and sporadic Currarino cases". Eur J Med Genet. 56 (12): 648–54. doi:10.1016/j.ejmg.2013.09.011. PMID   24095820.
  7. Zhang, W., Huang, L., Lu, X., Wang, K., Ning, X., & Liu, Z. (2019). Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. Bosnian journal of basic medical sciences, 19(2), 164–171. https://doi.org/10.17305/bjbms.2019.3713

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.