PRRX2

PRRX2
Identifiers
Aliases	PRRX2 , PMX2, PRX2, paired related homeobox 2
External IDs	OMIM: 604675; MGI: 98218; HomoloGene: 7524; GeneCards: PRRX2; OMA:PRRX2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.11 Start 129,665,647 bp [1] End 129,722,674 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 B|2 21.74 cM Start 30,724,984 bp [2] End 30,771,263 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta periodontal fiber Descending thoracic aorta gingival epithelium tibial arteries vena cava gonad skin of leg canal of the cervix cartilage tissue Top expressed in hand calvaria maxillary prominence mandibular prominence external carotid artery nasal septum upper jaw dermis foot abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51450 20204 Ensembl ENSG00000167157 ENSMUSG00000039476 UniProt Q99811 Q06348 RefSeq (mRNA) NM_016307 NM_009116 RefSeq (protein) NP_057391 NP_033142 Location (UCSC) Chr 9: 129.67 – 129.72 Mb Chr 2: 30.72 – 30.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene. ^{[5] [6]}

Function

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000167157 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039476 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome. 11 (11): 1000–5. doi:10.1007/s003350010193. PMID   11063257. S2CID   9937434.
6. "Entrez Gene: PRRX2 paired related homeobox 2".

Further reading

• Tokutomi Y, Araki N, Kataoka K, et al. (2007). "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis". Biochem. Biophys. Res. Commun. 364 (4): 822–30. doi:10.1016/j.bbrc.2007.10.095. PMID   17964282.
• Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC   1421504 . PMID   16582099.
• Gervais C, Mauvieux L, Perrusson N, et al. (2005). "A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia". Leukemia. 19 (1): 145–8. doi: 10.1038/sj.leu.2403565 . PMID   15496970.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Scott KK, Norris RA, Potter SS, et al. (2003). "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein". DNA Cell Biol. 22 (2): 95–105. doi:10.1089/104454903321515904. PMID   12713735.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jones FS, McKean DM, Meech R, et al. (2002). "Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes". Chest. 121 (3 Suppl): 89S –90S. doi:10.1378/chest.121.3_suppl.89S-a. PMID   11893718.
• Stelnicki EJ, Arbeit J, Cass DL, et al. (1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J. Invest. Dermatol. 111 (1): 57–63. doi: 10.1046/j.1523-1747.1998.00238.x . PMID   9665387.