FOXH1

Last updated
FOXH1
Identifiers
Aliases FOXH1 , FAST-1, FAST1, forkhead box H1
External IDs OMIM: 603621 MGI: 1347465 HomoloGene: 2914 GeneCards: FOXH1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003923

NM_007989

RefSeq (protein)

NP_003914

NP_032015

Location (UCSC) Chr 8: 144.47 – 144.48 Mb Chr 15: 76.55 – 76.55 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene. [5] [6]

Contents

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [6]

FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.

Interactions

FOXH1 has been shown to interact with DRAP1 [7] and Mothers against decapentaplegic homolog 2. [8] [9] [10] [11] [12]

See also

Related Research Articles

<span class="mw-page-title-main">Paracrine signaling</span>

Paracrine signaling is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce changes in nearby cells, altering the behaviour of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance, as opposed to cell signaling by endocrine factors, hormones which travel considerably longer distances via the circulatory system; juxtacrine interactions; and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.

<span class="mw-page-title-main">Mothers against decapentaplegic homolog 2</span> Protein-coding gene in the species Homo sapiens

Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

<span class="mw-page-title-main">Mothers against decapentaplegic homolog 3</span> Protein-coding gene in humans

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<span class="mw-page-title-main">Mothers against decapentaplegic homolog 4</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">Mothers against decapentaplegic homolog 6</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Mothers against decapentaplegic homolog 7</span> Protein-coding gene in the species Homo sapiens

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Smads comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. The abbreviation refers to the homologies to the Caenorhabditis elegans SMA and MAD family of genes in Drosophila.

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<span class="mw-page-title-main">ACVR1C</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ACVR1B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ACVR1</span> Protein-coding gene

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<span class="mw-page-title-main">ACVR2A</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ACVR2B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TGF beta receptor 1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Lymphoid enhancer-binding factor 1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PIAS4</span> Protein-coding gene in the species Homo sapiens

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma, and is an enzyme that in humans is encoded by the PIAS4 gene.

<span class="mw-page-title-main">Homeobox protein TGIF1</span> Protein found in humans

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<span class="mw-page-title-main">MECOM</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">FOXG1</span> Protein-coding gene in the species Homo sapiens

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The Nodal signaling pathway is a signal transduction pathway important in regional and cellular differentiation during embryonic development.

References

  1. ·     Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
  2. Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
  3. ·     von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023
  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160973 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033837 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. 1 2 "Entrez Gene: FOXH1 forkhead box H1".
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  9. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology. 19 (1): 424–430. doi:10.1128/MCB.19.1.424. PMC   83900 . PMID   9858566.
  10. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development. 11 (23): 3157–3167. doi:10.1101/gad.11.23.3157. PMC   316747 . PMID   9389648.
  11. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology. 20 (17): 6201–6211. doi:10.1128/MCB.20.17.6201-6211.2000. PMC   86095 . PMID   10938097.
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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.