TCF15

TCF15
Identifiers
Aliases	TCF15 , EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15
External IDs	OMIM: 601010 MGI: 104664 HomoloGene: 37943 GeneCards: TCF15
Gene location (Human)
Chr.	Chromosome 20 (human)
End	610,309 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,149,097 bp
Gene ontology
Molecular function	• DNA binding ; • protein dimerization activity ; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	• nucleus ; • RNA polymerase II transcription regulator complex ;
Biological process	• somitogenesis ; • respiratory system process ; • regulation of transcription, DNA-templated ; • muscle organ morphogenesis ; • eating behavior ; • neuromuscular process controlling posture ; • regulation of transcription by RNA polymerase II ; • skeletal system morphogenesis ; • muscle organ development ; • ear development ; • transcription, DNA-templated ; • multicellular organism development ; • establishment of epithelial cell apical/basal polarity ; • regulation of extracellular matrix organization ; • post-anal tail morphogenesis ; • regulation of gene expression ; • mesoderm development ; • anterior/posterior pattern specification ; • skin development ; • paraxial mesoderm development ; • mesenchymal to epithelial transition ; • transcription by RNA polymerase II ; • positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	6939
	21407
	ENSG00000125878
	ENSMUSG00000068079
	Q12870
	Q60756
	NM_004609
	NM_009328
	NP_004600
	NP_033354
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 22, 2021

Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene. ^[5]

Function

The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].

Related Research Articles

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Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.

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Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.

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Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.

Musculin is a protein that in humans is encoded by the MSC gene.

Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene.

Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene. The FIGLA gene is a germ cell-specific transcription factor preferentially expressed in oocytes that can be found on human chromosome 2p13.3.

Basic helix-loop-helix family, member a9 is a protein in humans that is encoded by the BHLHA9 gene.

Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125878 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068079 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Transcription factor 15" . Retrieved 2017-11-09.

TCF15

Contents

Function

Related Research Articles

References

Further reading