HOXB9

Last updated
HOXB9
Identifiers
Aliases HOXB9 , HOX-2.5, HOX2, HOX2E, homeobox B9
External IDs OMIM: 142964; MGI: 96190; HomoloGene: 7367; GeneCards: HOXB9; OMA:HOXB9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024017

NM_008270

RefSeq (protein)

NP_076922

NP_032296

Location (UCSC) Chr 17: 48.62 – 48.63 Mb Chr 11: 96.16 – 96.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene. [5] [6] [7]

Contents

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [7]

Interactions

HOXB9 has been shown to interact with BTG2 [8] and BTG1. [8]

See also

Related Research Articles

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Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.

<span class="mw-page-title-main">HOXB5</span> Protein-coding gene in humans

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

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<span class="mw-page-title-main">HOXC8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

<span class="mw-page-title-main">HOXA7</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

<span class="mw-page-title-main">HOXB1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXD3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

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Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

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<span class="mw-page-title-main">HOXC13</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.

<span class="mw-page-title-main">HOXB8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HOXC9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">HOXC10</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.

<span class="mw-page-title-main">HOXA6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A6 is a protein that in humans is encoded by the HOXA6 gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170689 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020875 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
  7. 1 2 "Entrez Gene: HOXB9 homeobox B9".
  8. 1 2 Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi: 10.1074/jbc.275.1.147 . PMID   10617598.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.