VSX2

VSX2
Identifiers
Aliases	VSX2 , CHX10, HOX10, MCOP2, MCOPCB3, RET1, visual system homeobox 2
External IDs	OMIM: 142993 MGI: 88401 HomoloGene: 7266 GeneCards: VSX2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,262,738 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,642,231 bp
RNA expression pattern
	Top expressed in
	lymph node; ; nucleus of brain; ; substantia nigra; ; subcutaneous adipose tissue; ; hypothalamus; ; anterior pituitary; ; gonad;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding ; DNA binding ; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	multicellular organism development ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; response to stimulus ; visual perception ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	338917
	12677
	ENSG00000119614
	ENSMUSG00000021239
	P58304
	Q61412
	NM_182894
	NM_001301427 ; NM_007701
	NP_878314
	NP_001288356 ; NP_031727
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 21, 2022

Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119614 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021239 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

Sanger Centre, The; Washington University Genome Sequencing Centre, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–1108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Ferda Percin E, Ploder LA, Yu JJ, et al. (2000). "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10". Nat. Genet. 25 (4): 397–401. doi:10.1038/78071. PMID 10932181. S2CID 9508022.
Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". J. Biol. Chem. 276 (6): 4109–4118. doi: 10.1074/jbc.M008882200 . PMID 11069920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–607. doi: 10.1038/nature01348 . PMID 12508121.
Bar-Yosef U, Abuelaish I, Harel T, et al. (2005). "CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds". Hum. Genet. 115 (4): 302–309. doi:10.1007/s00439-004-1154-2. PMID 15257456. S2CID 28981190.
Dorval KM, Bobechko BP, Ahmad KF, Bremner R (2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1". J. Biol. Chem. 280 (11): 10100–10108. doi: 10.1074/jbc.M412676200 . PMID 15647262.
Kuiper H, Spötter A, Williams JL, et al. (2005). "Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34". Cytogenet. Genome Res. 109 (4): 533. doi: 10.1159/000084217 . PMID 15909363.
Dorval KM, Bobechko BP, Fujieda H, et al. (2006). "CHX10 targets a subset of photoreceptor genes". J. Biol. Chem. 281 (2): 744–751. doi: 10.1074/jbc.M509470200 . PMID 16236706.
Faiyaz-Ul-Haque M, Zaidi SH, Al-Mureikhi MS, et al. (2007). "Mutations in the CHX10 gene in non-syndromic microphthalmia/anophthalmia patients from Qatar". Clin. Genet. 72 (2): 164–166. doi:10.1111/j.1399-0004.2007.00846.x. PMID 17661825. S2CID 6218901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119614 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021239 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-6] "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

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VSX2

Related Research Articles

References

Further reading