HOXD12

Last updated
HOXD12
Identifiers
Aliases HOXD12 , HOX4H, homeobox D12
External IDs OMIM: 142988; MGI: 96204; HomoloGene: 7369; GeneCards: HOXD12; OMA:HOXD12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021193

NM_008274

RefSeq (protein)

NP_067016

NP_032300

Location (UCSC) Chr 2: 176.1 – 176.1 Mb Chr 2: 74.51 – 74.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene. [5] [6] [7]

Contents

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd12 gene plays a role in axial skeleton development and forelimb morphogenesis. [8]

See also

Related Research Articles

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<span class="mw-page-title-main">HOXD3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

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Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

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<span class="mw-page-title-main">HOXD4</span> Protein-coding gene

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

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<span class="mw-page-title-main">HOXD1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">HOXD8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HOXC11</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170178 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001823 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. D'Esposito M, Morelli F, Acampora D, Migliaccio E, Simeone A, Boncinelli E (July 1991). "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Genomics. 10 (1): 43–50. doi:10.1016/0888-7543(91)90482-T. PMID   1675198.
  6. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  7. "Entrez Gene: HOXD12 homeobox D12".
  8. Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse" . Development. 122 (4): 1175–85. doi:10.1242/dev.122.4.1175. PMID   8620844.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.