MXI1

Last updated
MXI1
Identifiers
Aliases MXI1 , MAD2, MXD2, MXI, bHLHc11, MAX interactor 1, dimerization protein
External IDs OMIM: 600020; MGI: 97245; HomoloGene: 4351; GeneCards: MXI1; OMA:MXI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130439
NM_001008541
NM_005962

RefSeq (protein)

NP_001008541
NP_005953
NP_569157

Location (UCSC) Chr 10: 110.21 – 110.29 Mb Chr 19: 53.3 – 53.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene. [5] [6]

Contents

Function

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [6]

Interactions

MXI1 has been shown to interact with SMC3 [7] and MAX. [7] [8] [9] [10] [11]

Related Research Articles

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

<span class="mw-page-title-main">N-Myc</span> Protein-coding gene in the species Homo sapiens

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

<span class="mw-page-title-main">MYC</span> Protein-coding gene in the species Homo sapiens

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.

<span class="mw-page-title-main">ID2</span> Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

<span class="mw-page-title-main">MYBL2</span> Protein-coding gene in the species Homo sapiens

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

<span class="mw-page-title-main">FLI1</span> Protein-coding gene in the species Homo sapiens

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.

<span class="mw-page-title-main">ID1</span> Protein-coding gene in the species Homo sapiens

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.

<span class="mw-page-title-main">MAX (gene)</span> Protein-coding gene in humans

MAX is a gene that in humans encodes the MAX transcription factor.

<i>ERG</i> (gene) Protein-coding gene in the species Homo sapiens

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

<span class="mw-page-title-main">ZBTB17</span> Protein-coding gene in the species Homo sapiens

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.

<span class="mw-page-title-main">TLX1</span> Protein coding gene in Humans

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.

<span class="mw-page-title-main">KDM5A</span> Protein-coding gene in the species Homo sapiens

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.

<span class="mw-page-title-main">MYCL</span> Protein-coding gene in the species Homo sapiens

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.

<span class="mw-page-title-main">N-myc-interactor</span> Protein-coding gene in the species Homo sapiens

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

<span class="mw-page-title-main">GFI1</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis.

<span class="mw-page-title-main">MXD1</span> Protein-coding gene in the species Homo sapiens

MAD protein is a protein that in humans is encoded by the MXD1 gene.

<i>ERF</i> (gene) Protein-coding gene in the species Homo sapiens

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.

<span class="mw-page-title-main">MNT (gene)</span> Protein-coding gene in the species Homo sapiens

MNT is a Max-binding protein that is encoded by the MNT gene

<span class="mw-page-title-main">PATZ1</span> Protein-coding gene in the species Homo sapiens

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

mir-22

In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119950 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025025 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics. 21 (3): 669–72. doi: 10.1006/geno.1994.1336 . PMID   7959753.
  6. 1 2 "Entrez Gene: MXI1 MAX interactor 1".
  7. 1 2 Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi: 10.1038/sj.onc.1201634 . PMID   9528857.
  8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  9. Billin AN, Eilers AL, Queva C, Ayer DE (Dec 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi: 10.1074/jbc.274.51.36344 . PMID   10593926.
  10. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC   1169897 . PMID   9184233.
  11. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi: 10.1038/sj.onc.1202611 . PMID   10229200.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.