MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene. [5] [6]
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [6]
MXI1 has been shown to interact with SMC3 [7] and MAX. [7] [8] [9] [10] [11]
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.
MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.
DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.
MAX is a gene that in humans encodes the MAX transcription factor.
ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.
Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.
T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.
Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.
N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.
Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis.
MAD protein is a protein that in humans is encoded by the MXD1 gene.
ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.
MNT is a Max-binding protein that is encoded by the MNT gene
POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.
In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.