Structure specific recognition protein 1

Last updated
SSRP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SSRP1 , FACT, FACT80, T160, Structure specific recognition protein 1
External IDs OMIM: 604328; MGI: 107912; HomoloGene: 110735; GeneCards: SSRP1; OMA:SSRP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003146

NM_001136081
NM_182990

RefSeq (protein)

NP_003137

NP_001129553
NP_892035

Location (UCSC) Chr 11: 57.33 – 57.34 Mb Chr 2: 84.87 – 84.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene. [5]

Contents

Function

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. [5]

Interactions

Structure specific recognition protein 1 has been shown to interact with NEK9. [6] SSRP1 further interacts with transcriptional activator p63. [7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149136 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027067 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SSRP1 structure specific recognition protein 1".
  6. Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi: 10.1074/jbc.M311477200 . PMID   14660563.
  7. Zeng SX, Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC   129072 . PMID   12374749.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.