SUPT16H

SUPT16H
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5E5B, 4Z2M, 4Z2N
Identifiers
Aliases	SUPT16H , CDC68, FACTP140, SPT16/CDC68, SPT16, SPT16 homolog, facilitates chromatin remodeling subunit, NEDDFAC
External IDs	OMIM: 605012; MGI: 1890948; HomoloGene: 5207; GeneCards: SUPT16H; OMA:SUPT16H - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,384,019 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,434,873 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; testicle; ; Achilles tendon; ; epithelium of colon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; body of uterus; ; smooth muscle tissue;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; genital tubercle; ; tail of embryo; ; neural layer of retina; ; primitive streak; ; renal corpuscle; ; epiblast; ; tibiofemoral joint; ; medullary collecting duct; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; nucleosome binding ; histone binding ; RNA binding ;
Cellular component	nucleus ; nucleoplasm ; chromosome ; FACT complex ;
Biological process	positive regulation of DNA-templated transcription, elongation ; DNA replication ; nucleosome disassembly ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; DNA repair ; transcription, DNA-templated ; cellular response to DNA damage stimulus ; regulation of signal transduction by p53 class mediator ; transcription elongation from RNA polymerase II promoter ; positive regulation of transcription elongation from RNA polymerase II promoter ;
	Sources:Amigo / QuickGO
Orthologs
	11198
	114741
	ENSG00000092201
	ENSMUSG00000035726
	Q9Y5B9
	Q920B9
	NM_007192
	NM_033618
	NP_009123
	NP_291096
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 07, 2024

FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.^[5]^[6]^[7]

Function

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.^[7]

Interactions

SUPT16H has been shown to interact with BAZ1B.^[8]

Related Research Articles

A nucleosome is the basic structural unit of DNA packaging in eukaryotes. The structure of a nucleosome consists of a segment of DNA wound around eight histone proteins and resembles thread wrapped around a spool. The nucleosome is the fundamental subunit of chromatin. Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4.

Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. Gene transcription occurs in both eukaryotic and prokaryotic cells. Unlike prokaryotic RNA polymerase that initiates the transcription of all different types of RNA, RNA polymerase in eukaryotes comes in three variations, each translating a different type of gene. A eukaryotic cell has a nucleus that separates the processes of transcription and translation. Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control.

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

Histone H2B type 1-M is a protein that in humans is encoded by the HIST1H2BM gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

FACT is a heterodimeric protein complex that affects eukaryotic RNA polymerase II transcription elongation both in vitro and in vivo. It was discovered in 1998 as a factor purified from human cells that was essential for productive, in vitro Pol II transcription on a chromatinized DNA template.

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene.

General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene.

In the field of molecular biology, the Mi-2/NuRDcomplex, is a group of associated proteins with both ATP-dependent chromatin remodeling and histone deacetylase activities. As of 2007, Mi-2/NuRD was the only known protein complex that couples chromatin remodeling ATPase and chromatin deacetylation enzymatic functions.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092201 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035726 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (Mar 1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi: 10.1016/S0092-8674(00)80903-4 . PMID 9489704.
↑ Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (Mar 2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol Cell. 7 (2): 283–92. doi: 10.1016/S1097-2765(01)00176-9 . PMID 11239457.
1 2 "Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)".
↑ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi: 10.1016/S0092-8674(03)00436-7 . PMID 12837248. (Retracted, see doi:10.1016/j.cell.2012.03.008, PMID 22464333, Retraction Watch . If this is an intentional citation to a retracted paper, please replace {{ retracted |...}} with {{ retracted |...|intentional=yes}}.)

External links

Overview of all the structural information available in the PDB for UniProt : Q9Y5B9 (FACT complex subunit SPT16) at the PDBe-KB .

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092201 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035726 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9489704-5] Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (Mar 1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi: 10.1016/S0092-8674(00)80903-4 . PMID 9489704.

[pmid11239457-6] Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (Mar 2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol Cell. 7 (2): 283–92. doi: 10.1016/S1097-2765(01)00176-9 . PMID 11239457.

[entrez-7] 1 2 "Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)".

[pmid12837248-8] Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi: 10.1016/S0092-8674(03)00436-7 . PMID 12837248. (Retracted, see doi:10.1016/j.cell.2012.03.008, PMID 22464333, Retraction Watch . If this is an intentional citation to a retracted paper, please replace {{ retracted |...}} with {{ retracted |...|intentional=yes}}.)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]