NEK9

NEK9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZKE, 3ZKF
Identifiers
Aliases	NEK9 , NERCC, NERCC1, Nek8, NIMA related kinase 9, APUG, LCCS10, NC
External IDs	OMIM: 609798 MGI: 2387995 HomoloGene: 13222 GeneCards: NEK9
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,127,344 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,386,136 bp
RNA expression pattern
	Top expressed in
	tibia; ; right uterine tube; ; canal of the cervix; ; gastrocnemius muscle; ; stromal cell of endometrium; ; gastric mucosa; ; germinal epithelium; ; left uterine tube; ; tibial nerve; ; right coronary artery;
	Top expressed in
	vastus lateralis muscle; ; iris; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; utricle; ; temporal muscle; ; ureter; ; endocardial cushion; ; medullary collecting duct; ; digastric muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; metal ion binding ; kinase activity ; protein binding ; ATP binding ; protein kinase binding ; protein serine/threonine kinase activity ;
Cellular component	cytosol ; nucleus ; cytoplasm ; centrosome ;
Biological process	phosphorylation ; cell division ; mitotic nuclear membrane disassembly ; cell cycle ; protein phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	91754
	217718
	ENSG00000119638
	ENSMUSG00000034290
	Q8TD19
	Q8K1R7
	NM_033116 ; NM_001329237 ; NM_001329238
	NM_145138
	NP_001316166 ; NP_001316167 ; NP_149107
	NP_660120
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.^[5]^[6]

Interactions

NEK9 has been shown to interact with:

Related Research Articles

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

Tuberous Sclerosis Complex 2 (TSC2), also known as Tuberin, is a protein that in humans is encoded by the TSC2 gene.

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.

Stratifin is a protein encoded by the SFN gene in humans. The protein is named for its presence in stratified epithelial cells.

Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase, is an enzyme that in humans is encoded by the RPS6KB1 gene. It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. As the name suggests, its target substrate is the S6 ribosomal protein. Phosphorylation of S6 induces protein synthesis at the ribosome.

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene. RAP2A is a member of the Ras-related protein family.

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.

Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 is an enzyme that in humans is encoded by the MAP3K2 gene.

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119638 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034290 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD (May 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". The Journal of Biological Chemistry. 277 (18): 16229–40. doi: 10.1074/jbc.M108662200 . PMID 11864968.
↑ "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
↑ Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". The Journal of Biological Chemistry. 278 (37): 34897–909. doi: 10.1074/jbc.M303663200 . PMID 12840024.
1 2 Roig J, Mikhailov A, Belham C, Avruch J (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes & Development. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374 . PMID 12101123.
↑ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". The Journal of Biological Chemistry. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.

Pelka P, Scimè A, Mandalfino C, Joch M, Abdulla P, Whyte P (Jul 2007). "Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase". Journal of Cellular Physiology. 212 (1): 13–25. doi:10.1002/jcp.20983. PMID 17443675. S2CID 41137896.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (Mar 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). Molecular & Cellular Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . PMID 17192257.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Bowers AJ, Boylan JF (Mar 2004). "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors". Gene. 328: 135–42. doi:10.1016/j.gene.2003.12.002. PMID 15019993.
Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". The Journal of Biological Chemistry. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". The Journal of Biological Chemistry. 278 (37): 34897–909. doi: 10.1074/jbc.M303663200 . PMID 12840024.
Roig J, Mikhailov A, Belham C, Avruch J (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes & Development. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374 . PMID 12101123.
Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, Takahashi Y, Kitajima S, Saga Y, Koseki H (Apr 2002). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Research. 9 (2): 47–57. doi: 10.1093/dnares/9.2.47 . PMID 12056414.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119638 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034290 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11864968-5] Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD (May 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". The Journal of Biological Chemistry. 277 (18): 16229–40. doi: 10.1074/jbc.M108662200 . PMID 11864968.

[entrez-6] "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[pmid12840024-8] Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". The Journal of Biological Chemistry. 278 (37): 34897–909. doi: 10.1074/jbc.M303663200 . PMID 12840024.

[pmid12101123-9] 1 2 Roig J, Mikhailov A, Belham C, Avruch J (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes & Development. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374 . PMID 12101123.

[pmid14660563-10] Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". The Journal of Biological Chemistry. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

NEK9

Contents

Interactions

Related Research Articles

References

Further reading