HOXC11

HOXC11
Identifiers
Aliases	HOXC11 , HOX3H, homeobox C11
External IDs	OMIM: 605559 MGI: 96193 HomoloGene: 130362 GeneCards: HOXC11
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.13 Start 53,973,126 bp [1] End 53,977,643 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F3|15 58.02 cM Start 102,862,862 bp [2] End 102,866,143 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery skin of abdomen saphenous vein muscle of leg gastrocnemius muscle subcutaneous adipose tissue skeletal muscle tissue Achilles tendon placenta kidney Top expressed in male urethra muscle tissue skeletal muscle tissue quadriceps femoris muscle spinal ganglia neural tube urinary bladder skin of limb kidney yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process multicellular organism development embryonic skeletal joint morphogenesis skeletal system development proximal/distal pattern formation embryonic digit morphogenesis endoderm development metanephros development regulation of transcription, DNA-templated organ induction anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3227 109663 Ensembl ENSG00000123388 ENSMUSG00000001656 UniProt O43248 P31313 RefSeq (mRNA) NM_014212 NM_001024842 RefSeq (protein) NP_055027 NP_001020013 Location (UCSC) Chr 12: 53.97 – 53.98 Mb Chr 15: 102.86 – 102.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene. ^{[5] [6] [7]}

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123388 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001656 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
6. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
7. "Entrez Gene: HOXC11 homeobox C11".

Further reading

• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–9108. doi: 10.1073/pnas.83.23.9104 . PMC   387083 . PMID   2878432.
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115. doi:10.1159/000134320. PMID   8646877.
• Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–267. doi:10.1016/S0014-5793(97)01118-6. PMID   9357979. S2CID   26075369.
• Mitchelmore C, Troelsen JT, Sjöström H, Norén O (1998). "The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription". J. Biol. Chem. 273 (21): 13297–13306. doi: 10.1074/jbc.273.21.13297 . PMID   9582375.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID   11857506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang X, Hamada J, Nishimoto A, et al. (2007). "HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells". J. Cell. Mol. Med. 11 (2): 299–306. doi:10.1111/j.1582-4934.2007.00020.x. PMC   3822828 . PMID   17488478.

External links

• HOXC11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.