KLF12

KLF12
Identifiers
Aliases	KLF12 , AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	OMIM: 607531 MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q22.1 Start 73,686,089 bp [1] End 74,133,929 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 E2.2-E2.3|14 50.9 cM Start 99,870,632 bp [2] End 100,284,679 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis superficial temporal artery retinal pigment epithelium caput epididymis Brodmann area 23 biceps brachii synovial joint internal globus pallidus ganglionic eminence saphenous vein Top expressed in retinal pigment epithelium dorsal tegmental nucleus habenula lateral geniculate nucleus medial geniculate nucleus pontine nuclei medial ganglionic eminence ventral tegmental area median eminence medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding transcription corepressor activity metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11278 16597 Ensembl ENSG00000118922 ENSMUSG00000072294 UniProt Q9Y4X4 O35738 RefSeq (mRNA) NM_007249 NM_016285 NM_010636 RefSeq (protein) NP_009180 NP_034766 Location (UCSC) Chr 13: 73.69 – 74.13 Mb Chr 14: 99.87 – 100.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene. ^{[5] [6]}

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. ^[6]

See also

• Kruppel-like factors

References

1. GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID   10704285.
6. "Entrez Gene: KLF12 Kruppel-like factor 12".

Further reading

• Imhof A, Schuierer M, Werner O, et al. (1999). "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor". Mol. Cell. Biol. 19 (1): 194–204. doi:10.1128/MCB.19.1.194. PMC   83878 . PMID   9858544.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Schuierer M, Hilger-Eversheim K, Dobner T, et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1". J. Biol. Chem. 276 (30): 27944–9. doi: 10.1074/jbc.M100070200 . PMID   11373277.
• Zhu CH, Huang Y, Broman MT, Domann FE (2001). "Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter". Biochim. Biophys. Acta. 1519 (1–2): 85–91. doi:10.1016/s0167-4781(01)00227-5. PMID   11406275.
• Chen C, Brabham WW, Stultz BG, et al. (2001). "Defining a common region of deletion at 13q21 in human cancers". Genes Chromosomes Cancer. 31 (4): 333–44. doi:10.1002/gcc.1152. PMID   11433524. S2CID   42200056.
• Rozenblum E, Vahteristo P, Sandberg T, et al. (2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum. Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID   11935316. S2CID   21371347.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Suda S, Rai T, Sohara E, et al. (2006). "Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter". Biochem. Biophys. Res. Commun. 344 (1): 246–52. doi:10.1016/j.bbrc.2006.03.138. PMID   16615998.

External links

• KLF12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.