KLF12

Last updated
KLF12
Identifiers
Aliases KLF12 , AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs OMIM: 607531 MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007249
NM_016285

NM_010636

RefSeq (protein)

NP_009180

NP_034766

Location (UCSC) Chr 13: 73.69 – 74.13 Mb Chr 14: 99.87 – 100.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene. [5] [6]

Contents

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [6]

See also

Related Research Articles

In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.

<span class="mw-page-title-main">KLF6</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.

<span class="mw-page-title-main">TRIM28</span> Protein-coding gene in the species Homo sapiens

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.

<span class="mw-page-title-main">CTBP1</span>

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

<span class="mw-page-title-main">KLF2</span> Protein-coding gene in the species Homo sapiens

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

<span class="mw-page-title-main">CTBP2</span> Protein-coding gene in the species Homo sapiens

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.

<span class="mw-page-title-main">DRAP1</span>

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.

<span class="mw-page-title-main">KLF10</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

<span class="mw-page-title-main">KLF11</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.

<span class="mw-page-title-main">KLF13</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

<span class="mw-page-title-main">ZNF350</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.

<span class="mw-page-title-main">ZNF274</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

<span class="mw-page-title-main">ZFP161</span>

Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZFP161 gene.

<span class="mw-page-title-main">KLF3</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

<span class="mw-page-title-main">ZNF41</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.

<span class="mw-page-title-main">ZNF224</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.

<span class="mw-page-title-main">KLF7</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.

<span class="mw-page-title-main">ZNF160</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.

<span class="mw-page-title-main">KLF14</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.

<span class="mw-page-title-main">KLF15</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID   10704285.
  6. 1 2 "Entrez Gene: KLF12 Kruppel-like factor 12".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.