| KLF8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KLF8 , BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. [5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8. [6]
In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.
Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.
Kruppel-like factor 4 is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.
Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.
Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.
Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.
Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.
Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.
Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene. Previously known as Basic Transcription Element Binding Protein 1, Klf9 is part of the Sp1 C2H2-type zinc finger family of transcription factors. Several previous studies showed Klf9-related regulation of animal development, including cell differentiation of B cells, keratinocytes, and neurons. Klf9 is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, all factors that are essential during the process of pregnancy and are turned off during tumorigenesis.
Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.
Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.
Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.
Merlin Crossley, is an Australian molecular biologist, university teacher and administrator. In 2016, he was appointed as Deputy Vice-Chancellor (Academic) at the University of New South Wales.
Kruppel like factor 16 is a protein that in humans is encoded by the KLF16 gene.
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