KLF8

Last updated
KLF8
Identifiers
Aliases KLF8 , BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173780
NM_001357183

RefSeq (protein)

NP_776141
NP_001344112

Location (UCSC) Chr X: 56.23 – 56.29 Mb Chr X: 152.02 – 152.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. [5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8. [6]

Contents

Interactions

KLF8 has been shown to interact with CTBP2. [7]

Related Research Articles

In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.

<span class="mw-page-title-main">ATF3</span> Protein-coding gene in the species Homo sapiens

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

<span class="mw-page-title-main">KLF4</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 4 is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

<span class="mw-page-title-main">CTBP1</span> Protein-coding gene in the species Homo sapiens

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

<span class="mw-page-title-main">KLF5</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

<span class="mw-page-title-main">ZEB1</span> Protein-coding gene in the species Homo sapiens

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

<span class="mw-page-title-main">KLF2</span> Protein-coding gene in the species Homo sapiens

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

<span class="mw-page-title-main">ZNF148</span> Gene of the species Homo sapiens

Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.

<span class="mw-page-title-main">TFCP2</span> Protein-coding gene in the species Homo sapiens

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.

<span class="mw-page-title-main">CTBP2</span> Protein-coding gene in the species Homo sapiens

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.

<span class="mw-page-title-main">KLF11</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.

<span class="mw-page-title-main">KLF13</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

<span class="mw-page-title-main">KLF12</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

<span class="mw-page-title-main">FHL3</span> Protein-coding gene in the species Homo sapiens

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.

<span class="mw-page-title-main">KLF9</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene. Previously known as Basic Transcription Element Binding Protein 1, Klf9 is part of the Sp1 C2H2-type zinc finger family of transcription factors. Several previous studies showed Klf9-related regulation of animal development, including cell differentiation of B cells, keratinocytes, and neurons. Klf9 is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, all factors that are essential during the process of pregnancy and are turned off during tumorigenesis.

<span class="mw-page-title-main">KLF3</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

<span class="mw-page-title-main">KLF17</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.

<span class="mw-page-title-main">KLF15</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

Merlin Crossley, is an Australian molecular biologist, university teacher and administrator. In 2016, he was appointed as Deputy Vice-Chancellor (Academic) at the University of New South Wales.

<span class="mw-page-title-main">Kruppel like factor 16</span> Protein-coding gene in the species Homo sapiens

Kruppel like factor 16 is a protein that in humans is encoded by the KLF16 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KLF8 Kruppel-like factor 8".
  6. Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.
  7. van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC   103308 . PMID   10756197.

Further reading