Hes family bhlh transcription factor 2

HES2
Identifiers
Aliases	HES2 , bHLHb40, hes family bHLH transcription factor 2
External IDs	OMIM: 609970 MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Gene location (Human)
Chr.	Chromosome 1 (human) [1]
End	6,424,670 bp [1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse) [2]
End	152,162,469 bp [2]
Gene ontology
Molecular function	• DNA binding ; • double-stranded DNA binding ; • transcription factor binding ; • protein dimerization activity ; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific ; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ; • RNA polymerase II regulatory region sequence-specific DNA binding ; • GO:0001106 transcription corepressor activity ; • sequence-specific DNA binding ; • sequence-specific double-stranded DNA binding ;
Cellular component	• cell nucleus ;
Biological process	• negative regulation of transcription, DNA-templated ; • regulation of transcription, DNA-templated ; • transcription, DNA-templated ; • negative regulation of transcription from RNA polymerase II promoter ; • somitogenesis ; • Notch signaling pathway ; • cell differentiation ; • regulation of neurogenesis ; • anterior/posterior pattern specification ;
	Sources:Amigo / QuickGO
Orthologs
	54626
	15206
	ENSG00000069812
	ENSMUSG00000028940
	Q9Y543
	O54792
	NM_019089
	NM_001301805 ; NM_008236
	NP_061962
	NP_001288734 ; NP_032262
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 14, 2020

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.^[5]

Related Research Articles

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.

Transcription factor HES1 is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.

Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene.

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.

Lysine-specific demethylase 3B is an enzyme that in humans is encoded by the KDM3B gene. KDM3B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

Lysine-specific demethylase 4B is an enzyme that in humans is encoded by the KDM4B gene. KDM4B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.

Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.

Spermatogenesis-associated protein 5 is a protein that in humans is encoded by the SPATA5 gene.

Calmodulin-binding transcription activator 1 is a protein that in humans is encoded by the CAMTA1 gene.

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.

Gasdermin A is a protein that in humans is encoded by the GSDMA gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Hes family bHLH transcription factor 2".

Hes family bhlh transcription factor 2

Related Research Articles

References

Further reading