SOX12

SOX12
Identifiers
Aliases	SOX12 , SOX22, SRY-box 12, SRY-box transcription factor 12
External IDs	OMIM: 601947 MGI: 98360 HomoloGene: 5057 GeneCards: SOX12
Gene location (Human)
Chr.	Chromosome 20 (human)
End	330,224 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,239,983 bp
RNA expression pattern
	Top expressed in
	Ganglionic eminence; ; Stromal cell of endometrium; ; right uterine tube; ; sural nerve; ; internal globus pallidus; ; vena cava; ; renal medulla; ; amygdala; ; left lobe of thyroid gland; ; canal of the cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; GO:0001105 transcription coactivator activity ; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; GO:0000975 transcription cis-regulatory region binding ; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	protein-DNA complex ; nucleus ; nucleoplasm ; cellular component ;
Biological process	regulation of transcription by RNA polymerase II ; protein-DNA complex assembly ; cell fate commitment ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase II ; spinal cord development ; transcription, DNA-templated ; cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	6666
	20667
	ENSG00000177732
	ENSMUSG00000051817
	O15370
	Q04890
	NM_006943
	NM_011438
	NP_008874
	NP_035568
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 14, 2022

SOX12 is a protein that in humans is encoded by the SOX12 gene.^[5]^[6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.^[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.^[8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.^[6]

Related Research Articles

SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.

Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene. It is a member of the Sox gene family of transcription factors.

SRY -box 30 is a protein that in humans is encoded by the SOX30 gene.

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177732 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051817 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi: 10.1093/hmg/6.7.1069 . PMID 9215677.
1 2 "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
↑ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363 . PMID 18505825.
↑ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431 . PMID 18403418.

SOX12

Related Research Articles

References

Further reading