SPIB

SPIB
Identifiers
Aliases	SPIB , SPI-B, Spi-B transcription factor
External IDs	OMIM: 606802 MGI: 892986 HomoloGene: 79220 GeneCards: SPIB
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 50,418,938 bp [1] End 50,431,314 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B3|7 28.83 cM Start 44,525,993 bp [2] End 44,532,071 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • cell nucleus Biological process • regulation of transcription from RNA polymerase II promoter • cell differentiation • regulation of transcription, DNA-templated • transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6689	272382
Ensembl	ENSG00000269404	ENSMUSG00000008193
UniProt	Q01892	O35906
RefSeq (mRNA)	NM_003121 NM_001243998 NM_001243999 NM_001244000	NM_019866
RefSeq (protein)	NP_001230927 NP_001230928 NP_001230929 NP_003112	NP_063919
Location (UCSC)	Chr 19: 50.42 – 50.43 Mb	Chr 7: 44.53 – 44.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene. ^{[5] [6]}

Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM] ^[6]

Interactions

SPIB has been shown to interact with MAPK3 ^[7] and MAPK8. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000269404 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008193 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology. 12 (10): 4297–304. doi:10.1128/mcb.12.10.4297. PMC   360353 . PMID   1406622.
6. "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".
7. Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene. 12 (4): 863–73. PMID   8632909.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene. 12 (4): 863–73. PMID   8632909.
• Ray-Gallet D, Tavitian A, Moreau-Gachelin F (June 1996). "An alternatively spliced isoform of the Spi-B transcription factor". Biochemical and Biophysical Research Communications. 223 (2): 257–63. doi:10.1006/bbrc.1996.0881. PMID   8670269.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Rao S, Matsumura A, Yoon J, Simon MC (April 1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". The Journal of Biological Chemistry. 274 (16): 11115–24. doi: 10.1074/jbc.274.16.11115 . PMID   10196196.
• Nagy M, Chapuis B, Matthes T (February 2002). "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells". British Journal of Haematology. 116 (2): 429–35. doi: 10.1046/j.1365-2141.2002.03271.x . PMID   11841448. S2CID   22132659.
• Yamamoto H, Kihara-Negishi F, Yamada T, Suzuki M, Nakano T, Oikawa T (February 2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". Cell Growth & Differentiation. 13 (2): 69–75. PMID   11864910.
• Schotte R, Rissoan MC, Bendriss-Vermare N, Bridon JM, Duhen T, Weijer K, Brière F, Spits H (February 2003). "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development". Blood. 101 (3): 1015–23. doi: 10.1182/blood-2002-02-0438 . PMID   12393575.
• Schotte R, Nagasawa M, Weijer K, Spits H, Blom B (December 2004). "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development" (PDF). The Journal of Experimental Medicine. 200 (11): 1503–9. doi:10.1084/jem.20041231. PMC   2211952 . PMID   15583020.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Geng CD, Vedeckis WV (December 2005). "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter". The Journal of Biological Chemistry. 280 (52): 43264–71. doi: 10.1074/jbc.M508245200 . PMID   16263717.
• Dontje W, Schotte R, Cupedo T, Nagasawa M, Scheeren F, Gimeno R, Spits H, Blom B (March 2006). "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood. 107 (6): 2446–52. doi: 10.1182/blood-2005-05-2090 . PMID   16317090.

External links

• SPIB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.