MAPK3

Last updated
MAPK3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK3 , ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3
External IDs OMIM: 601795; MGI: 1346859; HomoloGene: 55682; GeneCards: MAPK3; OMA:MAPK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040056
NM_001109891
NM_002746

NM_011952

RefSeq (protein)

NP_001035145
NP_001103361
NP_002737

NP_036082

Location (UCSC) Chr 16: 30.11 – 30.12 Mb Chr 7: 126.36 – 126.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, [5] is an enzyme that in humans is encoded by the MAPK3 gene. [6]

Contents

Function

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAP kinase) family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [7]

Clinical significance

It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza A virus had been made to infect human lung cells. [8]

Signaling pathways

Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [9]

Interactions

MAPK3 has been shown to interact with:

Related Research Articles

A mitogen-activated protein kinase is a type of protein kinase that is specific to the amino acids serine and threonine. MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Biological crosstalk refers to instances in which one or more components of one signal transduction pathway affects another. This can be achieved through a number of ways with the most common form being crosstalk between proteins of signaling cascades. In these signal transduction pathways, there are often shared components that can interact with either pathway. A more complex instance of crosstalk can be observed with transmembrane crosstalk between the extracellular matrix (ECM) and the cytoskeleton.

<span class="mw-page-title-main">MAPK1</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 1, also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

<span class="mw-page-title-main">MAPK8</span> Protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase 8 is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

<span class="mw-page-title-main">MAP2K1</span> Protein-coding gene in the species Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.

<span class="mw-page-title-main">MAP2K2</span> Protein-coding gene in the species Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

<span class="mw-page-title-main">RPS6KA5</span> Enzyme

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

<span class="mw-page-title-main">RPS6KA2</span> Enzyme found in humans

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

<span class="mw-page-title-main">PTPRE</span> Protein-coding gene in the species Homo sapiens

Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.

<span class="mw-page-title-main">DUSP6</span> Protein-coding gene in humans

Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene.

<span class="mw-page-title-main">PTPN7</span> Protein-coding gene in the species Homo sapiens

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.

<span class="mw-page-title-main">MAPK8IP3</span> Protein-coding gene in the species Homo sapiens

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.

<span class="mw-page-title-main">PTPRR</span> Protein-coding gene in the species Homo sapiens

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

<span class="mw-page-title-main">DUSP3</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.

<span class="mw-page-title-main">MAPKAPK3</span> Protein-coding gene in the species Homo sapiens

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.

<span class="mw-page-title-main">DUSP4</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.

<span class="mw-page-title-main">DUSP10</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

<span class="mw-page-title-main">DUSP2</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

<span class="mw-page-title-main">DUSP16</span> Protein-coding gene in humans

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

<span class="mw-page-title-main">DUSP5</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.

References

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  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063065 Ensembl, May 2017
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  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Further reading