MARK3

MARK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QNJ, 3FE3
Identifiers
Aliases	MARK3 , CTAK1, KP78, PAR1A, Par-1a, microtubule affinity regulating kinase 3, VIPB
External IDs	OMIM: 602678 MGI: 1341865 HomoloGene: 55653 GeneCards: MARK3
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.32-q32.33 Start 103,385,377 bp [1] End 103,503,831 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 F1 Start 111,540,957 bp [2] End 111,622,655 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere body of pancreas left uterine tube right lung left adrenal gland left ventricle body of stomach right lobe of thyroid gland upper lobe of left lung monocyte Top expressed in spermatid molar proximal tubule ganglionic eminence saccule lens thymus left lung lobe superior frontal gyrus cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding ATP binding protein serine/threonine kinase activity tau protein binding tau-protein kinase activity Cellular component cytosol membrane extracellular exosome plasma membrane cytoplasm dendrite cell projection Biological process phosphorylation MAPK cascade protein phosphorylation microtubule cytoskeleton organization establishment of cell polarity negative regulation of hippo signaling peptidyl-serine phosphorylation positive regulation of protein binding intracellular signal transduction peptidyl-serine autophosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4140 17169 Ensembl ENSG00000075413 ENSMUSG00000007411 UniProt P27448 Q03141 RefSeq (mRNA) NM_001128918 NM_001128919 NM_001128920 NM_001128921 NM_002376 NM_021516 NM_022801 NM_001370744 NM_001370745 RefSeq (protein) NP_001122390 NP_001122391 NP_001122392 NP_001122393 NP_002367 NP_067491 NP_073712 NP_001357673 NP_001357674 Location (UCSC) Chr 14: 103.39 – 103.5 Mb Chr 12: 111.54 – 111.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene. ^{[5] [6]}

Interactions

MARK3 has been shown to interact with Stratifin. ^{[7] [8]}

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000075413 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007411 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ono T, Kawabe T, Sonta S, Okamoto T (April 1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 101–2. doi:10.1159/000134692. PMID   9533022.
6. "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
8. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
9. "Découverte d'un gène provoquant une cécité - Communiqués de presse - UNIGE". 23 July 2018.

Further reading

• Tassan JP, Le Goff X (2004). "An overview of the KIN1/PAR-1/MARK kinase family". Biol. Cell. 96 (3): 193–9. doi: 10.1016/j.biolcel.2003.10.009 . PMID   15182702.
• Meller N, Liu YC, Collins TL, Bonnefoy-Bérard N, Baier G, Isakov N, Altman A (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function". Mol. Cell. Biol. 16 (10): 5782–91. doi:10.1128/MCB.16.10.5782. PMC   231579 . PMID   8816492.
• Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H (1998). "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding". Cell Growth Differ. 9 (3): 197–208. PMID   9543386.
• Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID   11433294. S2CID   1128604.
• Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D (2003). "Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1". Oncogene. 22 (30): 4752–6. doi:10.1038/sj.onc.1206669. PMID   12879020. S2CID   9945293.
• Müller J, Ritt DA, Copeland TD, Morrison DK (2003). "Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate". EMBO J. 22 (17): 4431–42. doi:10.1093/emboj/cdg426. PMC   202368 . PMID   12941695.
• Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi: 10.1074/jbc.M304528200 . PMID   14594945.
• Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID   14760703. S2CID   8868600.
• Bachmann M, Hennemann H, Xing PX, Hoffmann I, Möröy T (2005). "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint". J. Biol. Chem. 279 (46): 48319–28. doi: 10.1074/jbc.M404440200 . PMID   15319445.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR (2007). "Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation". J. Cell Sci. 119 (Pt 19): 4059–70. doi:10.1242/jcs.03097. PMID   16968750. S2CID   582486.
• Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R (2006). "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases" (PDF). Mol. Cell. Biol. 26 (19): 7086–102. doi:10.1128/MCB.00231-06. PMC   1592903 . PMID   16980613.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID   17192257.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.