SNRK

SNRK
Identifiers
Aliases	SNRK , HSNFRK, SNF related kinase
External IDs	OMIM: 612760 MGI: 108104 HomoloGene: 9797 GeneCards: SNRK
Gene location (Human)
Chr.	Chromosome 3 (human)
End	43,424,764 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,998,768 bp
RNA expression pattern
	Top expressed in
	pericardium; ; visceral pleura; ; lower lobe of lung; ; cerebellar vermis; ; parietal pleura; ; superficial temporal artery; ; vena cava; ; urethra; ; renal medulla; ; bone marrow;
	Top expressed in
	cerebellar vermis; ; left lung lobe; ; superior cervical ganglion; ; brown adipose tissue; ; interventricular septum; ; subcutaneous adipose tissue; ; pontine nuclei; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein serine/threonine kinase activity ; ATP binding ; magnesium ion binding ; metal ion binding ; kinase activity ;
Cellular component	cytoplasm ; nucleus ;
Biological process	protein phosphorylation ; myeloid cell differentiation ; intracellular signal transduction ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	54861
	20623
	ENSG00000163788
	ENSMUSG00000038145
	Q9NRH2
	Q8VDU5
	NM_001100594 ; NM_017719 ; NM_001330750
	NM_001164572 ; NM_133741 ; NM_001357774 ; NM_001357775 ; NM_001357776
	NP_001094064 ; NP_001317679 ; NP_060189
	NP_001158044 ; NP_598502 ; NP_001344703 ; NP_001344704 ; NP_001344705
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 10, 2024

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.^[5]^[6]^[7]^[8]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163788 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038145 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Becker W, Heukelbach J, Kentrup H, Joost HG (February 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". European Journal of Biochemistry. 235 (3): 736–743. doi: 10.1111/j.1432-1033.1996.00736.x . PMID 8654423.
↑ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID 7788527.
↑ "Entrez Gene: SNRK SNF related kinase".
↑ Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, et al. (November 2019). "Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart". Journal of the American Heart Association. 8 (22): e012792. doi:10.1161/JAHA.119.012792. PMC 6915262 . PMID 31718444.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Iacobelli M, Wachsman W, McGuire KL (July 2000). "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein". Journal of Immunology. 165 (2): 860–868. doi: 10.4049/jimmunol.165.2.860 . PMID 10878360.
Yoshida K, Yamada M, Nishio C, Konishi A, Hatanaka H (August 2000). "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons". Brain Research. 873 (2): 274–282. doi:10.1016/S0006-8993(00)02548-8. PMID 10930554. S2CID 26034531.
Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL (September 2002). "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions". The Journal of Biological Chemistry. 277 (38): 34967–34977. doi: 10.1074/jbc.M205048200 . PMID 12087103.
Kertesz N, Samson J, Debacker C, Wu H, Labastie MC (July 2002). "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases". Gene. 294 (1–2): 13–24. doi:10.1016/S0378-1119(02)00829-6. PMID 12234663.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR (February 2005). "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate". FEBS Letters. 579 (6): 1417–1423. doi:10.1016/j.febslet.2005.01.042. PMID 15733851. S2CID 30479196.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163788 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038145 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8654423-5] Becker W, Heukelbach J, Kentrup H, Joost HG (February 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". European Journal of Biochemistry. 235 (3): 736–743. doi: 10.1111/j.1432-1033.1996.00736.x . PMID 8654423.

[pmid7788527-6] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID 7788527.

[entrez-7] "Entrez Gene: SNRK SNF related kinase".

[8] Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, et al. (November 2019). "Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart". Journal of the American Heart Association. 8 (22): e012792. doi:10.1161/JAHA.119.012792. PMC 6915262 . PMID 31718444.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SNRK

Related Research Articles

References

Further reading