CAMK2B

CAMK2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BHH
Identifiers
Aliases	CAMK2B , CAM2, CAMK2, CAMKB, calcium/calmodulin dependent protein kinase II beta, MRD54, CaMKIIbeta
External IDs	OMIM: 607707; MGI: 88257; HomoloGene: 111050; GeneCards: CAMK2B; OMA:CAMK2B - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p13 Start 44,217,150 bp [1] End 44,334,577 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 A1|11 3.89 cM Start 5,919,644 bp [2] End 6,016,362 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis lateral nuclear group of thalamus paraflocculus of cerebellum nucleus accumbens parietal lobe Brodmann area 9 right frontal lobe Top expressed in dentate gyrus of hippocampal formation granule cell CA3 field superior frontal gyrus primary visual cortex entorhinal cortex olfactory tubercle perirhinal cortex cerebellar cortex hippocampus proper nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding actin binding ATP binding protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding identical protein binding Cellular component endocytic vesicle membrane cytosol membrane plasma membrane nucleoplasm microtubule organizing center sarcoplasmic reticulum membrane sarcoplasmic reticulum cytoskeleton cytoplasm neuron projection cell junction synapse Biological process cell differentiation regulation of synapse structural plasticity regulation of calcium ion transport regulation of long-term neuronal synaptic plasticity interferon-gamma-mediated signaling pathway phosphorylation nervous system development MAPK cascade multicellular organism development positive regulation of synapse maturation protein phosphorylation positive regulation of neuron projection development protein autophosphorylation regulation of skeletal muscle adaptation positive regulation of dendritic spine morphogenesis regulation of dendritic spine development signal transduction peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction regulation of neuron migration regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 816 12323 Ensembl ENSG00000058404 ENSMUSG00000057897 UniProt Q13554 P28652 RefSeq (mRNA) NM_001220 NM_001293170 NM_172078 NM_172079 NM_172080 NM_172081 NM_172082 NM_172083 NM_172084 NM_001174053 NM_001174054 NM_007595 RefSeq (protein) NP_001211 NP_001280099 NP_742075 NP_742076 NP_742077 NP_742078 NP_742079 NP_742080 NP_742081 NP_001167524 NP_001167525 NP_031621 Location (UCSC) Chr 7: 44.22 – 44.33 Mb Chr 11: 5.92 – 6.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

Function

The enzyme belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. ^[5]

Interactions

CAMK2B has been shown to interact with Actinin alpha 4. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000058404 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057897 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta".
6. Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. doi:10.1523/JNEUROSCI.21-02-00423.2001. PMC   6763799 . PMID   11160423.

Further reading

• Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso. 47 (3): 241–7. PMID   11889801.
• Thiel G, Czernik AJ, Gorelick F, Nairn AC, Greengard P (1988). "Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6337–41. Bibcode:1988PNAS...85.6337T. doi: 10.1073/pnas.85.17.6337 . PMC   281965 . PMID   2842767.
• Schworer CM, Colbran RJ, Keefer JR, Soderling TR (1988). "Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains". J. Biol. Chem. 263 (27): 13486–9. doi: 10.1016/S0021-9258(18)68264-X . PMID   3417668.
• Penadés JR, Bernal D, Revert F, Johansson C, Fresquet VJ, Cervera J, Wieslander J, Quinones S, Saus J (1995). "Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms". Eur. J. Biochem. 229 (3): 754–60. doi:10.1111/j.1432-1033.1995.tb20524.x. PMID   7758473.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB (1997). "Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor". J. Biol. Chem. 271 (49): 31670–8. doi: 10.1074/jbc.271.49.31670 . PMID   8940188.
• Tombes RM, Krystal GW (1997). "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta. 1355 (3): 281–92. doi:10.1016/S0167-4889(96)00141-3. PMID   9060999.
• Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi: 10.1074/jbc.272.18.11832 . PMID   9115241.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Chang BH, Mukherji S, Soderling TR (1998). "Characterization of a calmodulin kinase II inhibitor protein in brain". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10890–5. Bibcode:1998PNAS...9510890C. doi: 10.1073/pnas.95.18.10890 . PMC   27991 . PMID   9724800.
• Rochlitz H, Voigt A, Lankat-Buttgereit B, Göke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AF (2000). "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells". Diabetologia. 43 (4): 465–73. doi: 10.1007/s001250051330 . PMID   10819240.
• Wang P, Wu YL, Zhou TH, Sun Y, Pei G (2000). "Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities". FEBS Lett. 475 (2): 107–10. doi: 10.1016/S0014-5793(00)01634-3 . PMID   10858498. S2CID   39732332.
• Novak G, Seeman P, Tallerico T (2001). "Schizophrenia: elevated mRNA for calcium-calmodulin-dependent protein kinase IIbeta in frontal cortex". Brain Res. Mol. Brain Res. 82 (1–2): 95–100. doi:10.1016/S0169-328X(00)00188-1. PMID   11042361.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB (2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. doi:10.1523/JNEUROSCI.21-02-00423.2001. PMC   6763799 . PMID   11160423.
• Liao GY, Wagner DA, Hsu MH, Leonard JP (2001). "Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current". Mol. Pharmacol. 59 (5): 960–4. doi:10.1124/mol.59.5.960. PMID   11306676.
• Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56. doi:10.1016/S0303-7207(01)00383-5. PMID   11325525. S2CID   338776.
• Schell MJ, Erneux C, Irvine RF (2001). "Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus". J. Biol. Chem. 276 (40): 37537–46. doi: 10.1074/jbc.M104101200 . PMID   11468283.
• Li G, Laabich A, Liu LO, Xue J, Cooper NG (2002). "Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calcium/calmodulin-dependent protein kinase II". Mol. Biol. Rep. 28 (1): 35–41. doi:10.1023/A:1011951814898. PMID   11710563. S2CID   22670733.
• Poggi A, Carosio R, Spaggiari GM, Fortis C, Tambussi G, Dell'Antonio G, Dal Cin E, Rubartelli A, Zocchi MR (2002). "NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain". J. Immunol. 168 (1): 95–101. doi: 10.4049/jimmunol.168.1.95 . PMID   11751951.

External links

• Human CAMK2B genome location and CAMK2B gene details page in the UCSC Genome Browser .